Results 41 to 50 of about 5,788,001 (267)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Power Preponderance and Domestic Politics: Explaining Regional Economic Integration in Latin America and the Caribbean, 1960-1997. Working Paper Series, Vol. 3, No. 1, August 2002 [PDF]
, 2002 (From the introduction). The promotion of regional integration is one of the more significant decisions in the post-WW II international political economy.
Hiroi, Taeko., Genna, Gaspare
core
Regional Digital Trade Integration Index (RDTII) (version 1 ) : a guide [PDF]
, 2022 The regional digital trade integration index (RDTII) results from cooperation among several United Nations Regional Commissions. Its development was initiated at ESCAP in 2020 as part of developing a broader Digital and Sustainable Regional Integration ...
UN.ECA, UN.ESCAP, UN.ECLAC
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Shifting paradigm of regional integration in Asia [PDF]
, 2007 The objective of this paper is to examine the prospects for and progress in economic interdependence and regional integration in Asia. In particular it focuses on the changing scenario in integration of South Asia into the rest of dynamic East and ...
Das, Dilip K.
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
A New Multi-Dimensional Framework for Analyzing Regional Integration: Regional Integration Evaluation (RIE) Methodology [PDF]
, 2010 Theories of regional integration typically analyze the regional integration process from the perspective of a single discipline, usually economics. However, such one-dimensional analytical frameworks cannot fully capture the richness and complexity of ...
Park, Donghyun +1 more
core
Евразийская интеграция: экономика, право, политика, 2022 This study discusses the results of using multidimensional statistical procedures in the analysis of development prospects and the state of regional integration of the countries of the Association of Southeast Asian Nations (ASEAN) and the countries of ...
A. M. Titovich, A. V. Toropygin
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source