Results 151 to 160 of about 8,399,847 (303)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang   +9 more
wiley   +1 more source

The Pollino national park in between ecology and development

open access: yesForest@, 2006
The Pollino national park covers an area of 192500 ha across Calabria and Basilicata regions (Southern Italy) and includes three main mountain ranges: “Massiccio del Pollino”, “Monti di Orsomarso” and “Monte Alpi”. Pinus leucodermis is the most important
Cocca C, Cocca D, Campanile G
doaj  

Areas administered by the National Park Service /

open access: yes, 1949
Vol. for 1965 includes the Registry of national landmarks.None published for 1958.Vol. for 1965 includes the Registry of national landmarks.Mode of access: Internet.Continued by: National parks & landmarks.Continues: National park system and other areas ...
United States. National Park Service.
core  

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

open access: yesAdvanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori   +10 more
wiley   +1 more source

Feasibility of Lower Neck Sparing in Postoperative Radiotherapy for Parotid Gland Cancer. [PDF]

open access: yesIn Vivo
Koh HK   +13 more
europepmc   +1 more source

Memorandum to Appalachian National Park Association

open access: yes, 2015
This memorandum from Chase Ambler to members of the Appalachian National Park Association is chiding them for not being more aggressively in sending out promotional literature.
Ambler, Chase P., 1865-1932;
core  

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang   +6 more
wiley   +1 more source

The Vascular Flora of Sirente-Velino Regional Park (Abruzzo, Central Italy). [PDF]

open access: yesBiology (Basel)
Conti F   +5 more
europepmc   +1 more source

Smokies: Peers of the Eastern Ranges in Nature

open access: yes, 2015
This article titled, “The Smokies: Peers of the Eastern Ranges,” was published in a 1928 issue of Nature Magazine. The article is illustrated with photographs by Jim Thompson. The magazine was collected by George Masa.
American Nature Association
core  

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

open access: yesAdvanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li   +23 more
wiley   +1 more source

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