Results 171 to 180 of about 8,399,847 (303)

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Global, regional, and national burden of chronic kidney disease attributable to dietary risks, 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021. [PDF]

Medicine (Baltimore)
Park J, Hwang SH, Oh J, Kang Y, Pizzol D, Smith L, Lee J, Lee H, Hwang HS, Yon DK.   +9 more
europepmc   +1 more source

Hierarchical Multi‐Mode Computing in Interlayer‐Coupled 3D RRAM Crossbar Arrays

Advanced Science, EarlyView.
2‐deck RRAM crossbar array provides a versatile hardware platform for multifunctional in‐memory computing. Stacked, series, and entropy node configurations enable multi‐layer conductance modulation, logic‐in‐memory operation, genetic learning, and reconfigurable physical unclonable functions.
Seungman Park, Jaewoo Choi, Gigon Nam, Junsu Yu, Donghyun Ryu, Jung‐Kyu Lee, Sungjoon Kim, Sungjun Kim   +7 more
wiley   +1 more source

Permafrost carbon release scales linearly with overshoot warming mediated by AMOC tipping. [PDF]

Nat Commun
Steinert NJ, Schwinger J, Burke E, Zhu B, Gasser T, Munday G, Mathison C, Park SW, Lee H.   +8 more
europepmc   +1 more source

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

Advanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan, James R. M. Black, Carlos Martínez‐Ruiz, Kristiana Grigoriadis, Jasmin Fisher, Nicholas McGranahan   +5 more
wiley   +1 more source

Scalable CT-based prognostic modeling of dementia conversion in mild cognitive impairment. [PDF]

Sci Rep
Park S, Ahn J, Na DL, Kim HJ, Jang H, Kim JP, Kang SH, Yun J, Chun MY, Seo SW, Kwak K.   +10 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Cerebellar Perfusion Changes After Repetitive Deep Transcranial Magnetic Stimulation in Parkinson's Disease: A Five-Patient Case Series and Literature Review. [PDF]

Diagnostics (Basel)
Song IU, Chung YA, Kim BS, Na S, Park SYJ.   +4 more
europepmc   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Web of Power in the Struggle for Access Rights to Forest Resources: Comparative Case Studies in Conservation and Industrial Forests. [PDF]

F1000Res
Rahmawati R, Rusliandy R, Mulyono IE, Harini S, Apriliyani NV, Salbiah E, Purnamasari I, Munjin RA, Ramdani FT, Sastrawan B, Satispi E, Andriansyah A, Lyndon NA.   +12 more
europepmc   +1 more source