Results 51 to 60 of about 26,753 (310)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Globalization and regionalisation: Determinants of the transformation and the process of the integration of the geo-space [PDF]
Glasnik Srpskog Geografskog Društva, 2005 The two processes that, basically since the emergence of the classic civilizations, determine major changes in the basic spatial structures in the world are, de facto, of antipode basic characteristics (globalization and regionalisation), but it is often
Todorović Marina J. +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Using geographical information systems for management of back-pain data [PDF]
, 2002 This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2002 MCB UP LtdIn the medical world, statistical visualisation has largely been confined to the realm of relatively simple ...
De Souza, LH +3 more
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Review of Economic Perspectives, 2015 The article analyses railway transport markets in three neighbouring Central European countries: the Czech Republic, Austria and Germany (specifically Bavaria and Saxony), with a focus on regional transportation.
Seidenglanz Daniel +2 more
doaj +1 more source
Comparative theory, China, and the future of East Asian regionalism(s) [PDF]
, 2010 Despite the development of an increasingly sophisticated literature on comparative regional integration drawing from a variety of cases, the European experience remains the most often used benchmark against which other integrative processes are judged ...
Breslin +18 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Belgeo, 2020 While the United Kingdom prepares to leave a weakened European Union, Brexit could mean a new stage in regionalisation in Europe, indeed in the world.
Mark Bailoni
doaj +1 more source