Results 71 to 80 of about 817,122 (295)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
El papel de la noción de conservación del área en la resignificación de la integral definida [PDF]
, 2012 El artículo analiza desde las prácticas del salón de clases, una resignificación del concepto de integral definida –visto como área bajo una curva– con estudiantes de una licenciatura en matemáticas, desde una perspectiva que articula usos, contextos y ...
Cabañas, Guadalupe, Cantoral, Ricardo
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Freer International Trade and the Consequences for EU rural areas [PDF]
General equilibrium models estimated by various authors and institutions show that, although trade liberalization leads to aggregate welfare gains, there are winners and losers when it comes to the distribution. The aim of this article is to determine to
Bureau, Jean-Christophe
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A review of the population structure of yellowfin tuna, Thunnus albacares, in the Eastern Pacific Ocean [PDF]
, 1964 ENGLISH: Since its inception in 1950 by agreement between the Republic of Costa Rica and the United States of America, the Inter-American Tropical Tuna Commission has been engaged in studies of the biology, ecology and population dynamics of yellowfin ...
Alverson, Franklin G. +3 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Wani¿Qué tan inclusivos de la diversidad étnica y de ¡género han sido los Consejos Regionales Autónomos de la Costa Caribe? ¿Cuál ha sido el compromiso de inclusión mostrado por los partidos políticos, incluyendo las organizaciones políticas regio- únales ...
Miguel González +2 more
doaj
Disparidades regionales en la Unión Europea. Una aproximación a la cuantificación de la cohesión económica y social [PDF]
, 2005 El Tratado de la Unión Europea (UE) de 1992 y el texto de la Constitución para Europa, actualmente en proceso de aprobación por los países miembros, establecen como uno de los principales objetivos de la Unión el logro de una más alta cohesión económica ...
Juan R. Cuadrado Roura +1 more
core +1 more source