Results 81 to 90 of about 1,340,538 (293)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Register-Shifted Structures in Base-Flipped Uracil-Damaged DNA

, 2023
We report the occurrence of register-shifted structures in simulations of uracil-containing dsDNA. These occur when the 3′ base vicinal to uracil is thymine in U:A base-paired DNA.
Paul B. Orndorff (16006658), Arjan van der Vaart, Paul B. Orndorff, Arjan van der Vaart (1289625)   +3 more
core   +1 more source

Lower 5-year cup re-revision rate for dual mobility cups compared with unipolar cups: report of 15,922 cup revision cases in the Dutch Arthroplasty Register (2007–2016)

Acta Orthopaedica, 2019
Background and purpose — During revision hip arthroplasty the dual mobility cup (DMC) is widely used to prevent dislocation despite limited knowledge of implant longevity. We determined the 5-year cup re-revision rates of DMC compared with unipolar cups (
Esther M Bloemheuvel, Liza N van Steenbergen, Bart A Swierstra   +2 more
doaj   +1 more source

Low revision rate of dual mobility cups after arthroplasty for acute hip fractures: report of 11,857 hip fractures in the Dutch Arthroplasty Register (2007–2019)

Acta Orthopaedica, 2020
Background and purpose — Dislocation is one of the most frequent reasons for cup revision after total hip arthroplasty (THA) for an acute fracture. A dual mobility cup (DMC) might reduce this risk.
Esther M Bloemheuvel, Liza N Van Steenbergen, Bart A Swierstra   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Primary constrained and hinged total knee arthroplasty: 2- and 5-year revision risk compared with unconstrained total knee arthroplasty: a report on 401 cases from the Norwegian Arthroplasty Register 1994–2017

Acta Orthopaedica, 2019
Background and purpose — The number of primary, highly constrained knee arthroplasty implants has increased with a theoretically increased risk of early failure.
Mona Badawy, Anne Marie Fenstad, Ove Furnes   +2 more
doaj   +1 more source

Fatigue Assessment of Very Large Container Ships Considering Springing Effect Based on Stochastic Approach

한국해양공학회지, 2020
Evaluation of fatigue strength considering the springing effect of very large container ships is crucial in the design stage. In this study, we established a fatigue strength evaluation method considering a linear springing component in the frequency ...
Byoung-Hoon Jung, In-Gyu Ahn, Sun-Kee Seo, Beom-Il Kim   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The Swedish Neonatal Quality Register – contents, completeness and validity

Acta paediatrica, 2019
To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.
M. Norman, K. Källén, Erik Wahlström, S. Håkansson   +3 more
semanticscholar   +1 more source

Stress Estimation Based on Stochastic Method for Strength Evaluation of Floating Wind Turbines

한국해양공학회지
Structural integrity assessment of floating wind turbine (FOWT) systems is performed based on fully coupled load analysis in time domain and structural analysis that consider the complex interactions among wind, wave, and currents.
Byungmo Kim, Beomil Kim
doaj   +1 more source