Results 91 to 100 of about 2,407,584 (300)

Novel shift register eliminates logic gates and power switching circuits [PDF]

, 1971
Register requiring two integrated circuits per stage has nominal power dissipation of 3.5 mW per stage, its use eliminates reset pulse, allowing data transfer to occur in less than 1 microsecond, and eliminates power application to both right and left ...
Cliff, R. A.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Computational capacity of the universe

, 2001
Merely by existing, all physical systems register information. And by evolving dynamically in time, they transform and process that information. The laws of physics determine the amount of information that a physical system can register (number of bits ...
A. Linde, A. S. Eddington, C. Monroe, C. Zalka, D. Abrams, D. G. Cory, H. Pagels, J. D. Bekenstein, J. D. Bekenstein, J. D. Bekenstein, L. Susskind, N. A. Gershenfeld, N. Margolus, N. Margolus, P. J. E. Peebles, P. Zizzi, P. Zizzi, Q. A. Turchette, R. Landauer, S. Lloyd, S. Lloyd, Seth Lloyd, T. Banks, Y. J. Ng, Y. J. Ng   +24 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

An automaton over data words that captures EMSO logic

, 2011
We develop a general framework for the specification and implementation of systems whose executions are words, or partial orders, over an infinite alphabet.
B. Bollig, Benedikt Bollig, Claire David, Daniel Brand, F. Neven, H. Björklund, L. Segoufin, M. Kaminski, M. Kaminski, M. Leucker, N. Tzevelekos, P. Bouyer, R. Alur, Stéphane Demri, T. Schwentick   +14 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Tracking of voluntary exercise behaviour over the lifespan

International Journal of Behavioral Nutrition and Physical Activity, 2019
Background The aim of many physical activity interventions is to develop life-long habits of regular exercise and sports activities in leisure time. Previous studies that assessed tracking (i.e. the stability of a trait over the lifespan) of leisure time
Matthijs D. van der Zee, Denise van der Mee, Meike Bartels, Eco J. C. de Geus   +3 more
doaj   +1 more source

Does cup position differ between trabecular metal and titanium cups? A radiographic propensity score matched study of 300 hips

Acta Orthopaedica, 2020
Background and purpose — The use of trabecular metal cups in primary total hip arthroplasty (THA) is increasing, despite the survival of Continuum cups being slightly inferior compared with other uncemented cups in registries.
Inari Laaksonen, Natalie Hjelmberg, Kirill Gromov, Antti E Eskelinen, Ola Rolfson, Henrik Malchau, Anders Troelsen, Keijo T Mäkelä, Maziar Mohaddes   +8 more
doaj   +1 more source

REGISTERS USED BY IKATAN WARIA MALANG (IWAMA) [PDF]

, 2005
Register is sets of vocabulary items associated with discrete occupation or social groups. Usually register used only among the member of certain group such as IWAMA.
Prasetya, Elman
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source