Results 61 to 70 of about 7,801,805 (293)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predicting the body core temperature of recreational athletes at the end of a 10 km self‐paced run under environmental heat stress

Experimental Physiology, 2023
Measurement of body core temperature (Tcore) is paramount to determining the thermoregulatory strain of athletes. However, standard measurement procedures of Tcore are not practical for extended use outside the laboratory environment.
Marcelo T. Andrade, Matheus M. S. Nunes‐Leite, Rúbio S. Bruzzi, Carlos H. Souza, João P. Uendeles‐Pinto, Luciano S. Prado, Danusa D. Soares, Dawit A. P. Gonçalves, Cândido C. Coimbra, Samuel P. Wanner   +9 more
doaj   +1 more source

Fast Kernel Smoothing in R with Applications to Projection Pursuit

Journal of Statistical Software, 2022
This paper introduces the R package FKSUM, which offers fast and exact evaluation of univariate kernel smoothers. The main kernel computations are implemented in C++, and are wrapped in simple, intuitive and versatile R functions.
David P. Hofmeyr
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Disjoint Contrastive Regression Learning for Multi-Sourced Annotations [PDF]

, 2021
Xiaoqian Ruan, Gaoang Wang
openalex   +1 more source

Private Incremental Regression

, 2017
Data is continuously generated by modern data sources, and a recent challenge in machine learning has been to develop techniques that perform well in an incremental (streaming) setting.
Chaudhuri K., Chaudhuri K., Fard M. M., Gordon Y., Jain P., Jain P., Jain P., Kabáan A., Kasiviswanathan S., Kifer D., Ledoux M., Maillard O., Mishra N., Shalev-Shwartz S., Talwar K., Thakurta A. G., Thakurta A. G., Vapnik V., Williams O.   +18 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Tensor Regression Networks [PDF]

, 2020
Convolutional neural networks typically consist of many convolutional layers followed by one or more fully connected layers. While convolutional layers map between high-order activation tensors, the fully connected layers operate on flattened activation ...
Anandkumar, Anima, Furlanello, Tommaso, Khanna, Aran, Kolbeinsson, Arinbjorn, Kossaifi, Jean, Lipton, Zachary C.   +5 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Learning Ultrametric Trees for Optimal Transport Regression [PDF]

, 2022
Samantha Chen, Puoya Tabaghi, Yusu Wang
openalex   +1 more source