Results 61 to 70 of about 2,557,184 (280)

MetaDiff: differential isoform expression analysis using random-effects meta-regression [PDF]

, 2015
Jia Cheng, Weihua Guan, Amy Yang, Rui Xiao, W.H. Wilson Tang, Christine S. Moravec, Kenneth B. Margulies, Thomas P. Cappola, Chun Li, Mingyao Li   +9 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

MODELING ROMANIANS’ LEVEL OF LIFE SATISFACTION [PDF]

Revista Română de Statistică, 2012
As a multi-dimensional indicator that captures the quality of life and wellbeing, the level of life satisfaction is very important for designing future policy The present analysis will focus on the study of life satisfaction based on the Romanian ...
Roxana-Otilia-Sonia HRIŢCU
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Regression without regrets –initial data analysis is a prerequisite for multivariable regression

BMC Medical Research Methodology
Statistical regression models are used for predicting outcomes based on the values of some predictor variables or for describing the association of an outcome with predictors.
Georg Heinze, Mark Baillie, Lara Lusa, Willi Sauerbrei, Carsten Oliver Schmidt, Frank E. Harrell, Marianne Huebner, on behalf of TG2 and TG3 of the STRATOS initiative   +7 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Bank Productivity: A Meta-Regression Analysis

Verimlilik Dergisi
Purpose: This study aims at examining studies employing the Malmquist Productivity Index (MPI) in calculating banks’ productivity. It also seeks to determine the factors affecting the total factor productivity change of banks through meta-regression ...
Neylan Kaya
doaj   +1 more source

Association of Obesity With COVID-19 Severity and Mortality: An Updated Systemic Review, Meta-Analysis, and Meta-Regression

, 2022
Romil Singh, Sawai Singh Rathore, Hira Khan, Smruti Karale, Yogesh Chawla, Kinza Iqbal, Abhishek Bhurwal, Aysun Tekin, Nirpeksh Jain, Ishita Mehra, Sohini Anand, Sanjana Reddy, Nikhil Sharma, Guneet Sidhu, Anastasios Panagopoulos, Vishwanath Pattan, Rahul Kashyap, Vikas Bansal   +17 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source