Results 91 to 100 of about 18,330,866 (262)
Remote Sensing, 2019 The spectral features of soils are a comprehensive representation of their physicochemical parameters, surface states, and internal structures. To date, spectral measurements have been mostly performed for powdered soils and smooth aggregate soils, but ...
Xiaojie Li +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
(Non) Linear Regression Modeling [PDF]
We will study causal relationships of a known form between random variables. Given a model, we distinguish one or more dependent (endogenous) variables Y = (Y1, . . .
Čížek, Pavel
core
Uniform Bahadur Representation for Local Polynomial Estimates of M-Regression and Its Application to The Additive Model [PDF]
, 2010 We use local polynomial fitting to estimate the nonparametric M-regression function for strongly mixing stationary processes {(Yi,Xi)}. We establish a strong uniform consistency rate for the Bahadur representation of estimators of the regression ...
Yingcun Xia +8 more
core +1 more source
Identification of Influential Points in a Linear Regression Model [PDF]
Statistika: Statistics and Economy Journal, 2011 The article deals with the detection and identification of influential points in the linear regression model. Three methods of detection of outliers and leverage points are described. These procedures can also be used for one-sample (independent)datasets.
Jan Grosz
doaj
Remote Sensing, 2019 To reduce the impacts of drought, developing an integrated drought monitoring tool and early warning system is crucial and more effective than the crisis management approach that is commonly used in developing countries like Ethiopia.
Yared Bayissa +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Poisson Ridge Regression Estimator [PDF]
The standard statistical method for analyzing count data is the Poisson regression model, which is usually estimated using maximum likelihood (ML). The ML method is very sensitive to multicollinearity. Therefore, we present a new Poisson ridge regression
Shukur, Ghazi, Månsson, Kristofer
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source