Results 71 to 80 of about 4,999,056 (283)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Graph Huber: a robust regression model for graph data

open access: yesXibei Gongye Daxue Xuebao
As it is increasingly prevalent that data contains noise or obeys heavy-tailed distribution, a robust regression model becomes one of focal and hot topics in many study fields.
SU Meihong   +3 more
doaj   +1 more source

Mapping Maize Water Stress Based on UAV Multispectral Remote Sensing

open access: yesRemote Sensing, 2019
Mapping maize water stress status and monitoring its spatial variability at a farm scale are a prerequisite for precision irrigation. High-resolution multispectral images acquired from an unmanned aerial vehicle (UAV) were used to evaluate the ...
Liyuan Zhang   +3 more
doaj   +1 more source

Doubly Robust Sure Screening for Elliptical Copula Regression Model

open access: yes, 2018
Regression analysis has always been a hot research topic in statistics. We propose a very flexible semi-parametric regression model called Elliptical Copula Regression (ECR) model, which covers a large class of linear and nonlinear regression models such
He, Yong   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Environmental aspects of the economic growth of Russian administrative regions

open access: yesЮг России: экология, развитие
The objective was to assess the relationship between the dynamics of economic growth and the level of pollutant emissions in the ecosystems of Russian administrative regions in the period from 1999 to 2023.The work uses methods for analysing the level of
N. S. Gichiev, N. O. Guseynova
doaj   +1 more source

Random model trees: an effective and scalable regression method [PDF]

open access: yes, 2010
We present and investigate ensembles of randomized model trees as a novel regression method. Such ensembles combine the scalability of tree-based methods with predictive performance rivaling the state of the art in numeric prediction.
Pfahringer, Bernhard
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Random Forest Regression May Become the Optimal Regression Model for Osteoarthritis of the Knee in Elderly, in the Context of Embodied Cognition and Psychosomatic Medicine

open access: yesJournal of Multidisciplinary Healthcare
Guangyuan Ma,1,* Junjie Chen,2,3,* Jingchi Li,2,3 Hui Shi,1 Yi Chen1 1School of Humanities and Management, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Department of Orthopedics, The Affiliated Traditional ...
Ma G, Chen J, Li J, Shi H, Chen Y
doaj  

Impact of Efficient Driving in Professional Bus Fleets

open access: yesEnergies, 2017
Diesel engines of the vehicles in the transport sector are responsible for most of the CO2 emissions into the environment. An alternative to reduce fuel consumption is to promote efficient driving techniques. The aim of this paper is to assess the impact
Roberto Garcia   +8 more
doaj   +1 more source

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