Results 61 to 70 of about 2,018,776 (304)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Environmental aspects of the economic growth of Russian administrative regions

Юг России: экология, развитие
The objective was to assess the relationship between the dynamics of economic growth and the level of pollutant emissions in the ecosystems of Russian administrative regions in the period from 1999 to 2023.The work uses methods for analysing the level of
N. S. Gichiev, N. O. Guseynova
doaj   +1 more source

Modelling Brain Lesion Volume in Patches with CNN-based Poisson Regression [PDF]

, 2020
Kevin Raina
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Random Forest Regression May Become the Optimal Regression Model for Osteoarthritis of the Knee in Elderly, in the Context of Embodied Cognition and Psychosomatic Medicine

Journal of Multidisciplinary Healthcare
Guangyuan Ma,1,* Junjie Chen,2,3,* Jingchi Li,2,3 Hui Shi,1 Yi Chen1 1School of Humanities and Management, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Department of Orthopedics, The Affiliated Traditional ...
Ma G, Chen J, Li J, Shi H, Chen Y
doaj  

MP62-10 UTILITY OF A MULTIVARIATE LOGISTIC REGRESSION MODEL FOR THE PREDICTION OF PROSTATE CANCER EXTRACAPSULAR EXTENSION BASED ON 3TMPMRI, CLINICAL, AND BIOPSY [PDF]

, 2020
Sohrab Afshari Mirak, R Reiter, Steven S. Raman   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Impact of Efficient Driving in Professional Bus Fleets

Energies, 2017
Diesel engines of the vehicles in the transport sector are responsible for most of the CO2 emissions into the environment. An alternative to reduce fuel consumption is to promote efficient driving techniques. The aim of this paper is to assess the impact
Roberto Garcia, Gabriel Diaz, Xabiel G. Pañeda, Alejandro G. Tuero, Laura Pozueco, David Melendi, Jose A. Sanchez, Victor Corcoba, Alejandro G. Pañeda   +8 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

NATIONAL AND REGIONAL COORDINATES OF THE REAL CONVERGENCE PROCESS INTENSITY IN THE ENLARGED EUROPEAN UNION [PDF]

CES Working Papers, 2012
Real convergence of EU economies can be approached from the perspective of close relations between the state of homogeneity and the existence of conditions that can facilitate it. In this paper we test the hypothesis of beta convergence at national level
Iulia Andreea Bucur
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