Results 101 to 110 of about 7,627,633 (340)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Regular phantom black holes

, 2005
For self-gravitating, static, spherically symmetric, minimally coupled scalar fields with arbitrary potentials and negative kinetic energy (favored by the cosmological observations), we give a classification of possible regular solutions to the field ...
J. C. Fabris, J. D. Bekenstein, K. A. Bronnikov, K. A. Bronnikov, K. A. Bronnikov, K. A. Bronnikov, R. Wald   +6 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Some Types of Regularity and Normality Axioms in Cech Fuzzy Soft Closure Spaces

Journal of New Theory, 2018
In the present paper, some types of regularity and normality axioms in Cech fuzzy soft closurespaces and their associative fuzzy soft topological spaces are defined and studied.
Lina Hussein Maibed, Rasha Naser Majeed
doaj  

Factorizations of the product of cycles

AKCE International Journal of Graphs and Combinatorics, 2019
An -factorization of a graph is a partition of the edge set of into spanning subgraphs (or factors) each of whose components are isomorphic to a graph Let be the Cartesian product of the cycles with for each El-Zanati and Eynden proved that has a ...
Y.M. Borse, A.V. Sonawane, S.R. Shaikh
doaj   +1 more source

Topological regular variation: III. Regular variation

Topology and its Applications, 2010
The paper extends the topological theory of regular variation of the slowly varying case of \textit{N. H. Bingham} and \textit{A. J. Ostaszewski} [Topology Appl. 157, No. 13, 1999--2013 (2010; Zbl 1202.26004)] to the regularly varying functions between metric groups, viewed as normed groups, cf. \textit{N. H. Bingham} and \textit{A. J.
Bingham, N.H., Ostaszewski, A.J.
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Diagonal Matrix Reduction over Refinement Rings

پژوهش‌های ریاضی, 2022
: A ring R is called a refinement ring if the monoid of finitely generated projective R- modules is refinement.  Let R be a commutative refinement ring and M, N, be two finitely generated projective R-nodules, then M~N  if and only if Mm ~Nm for all ...
Marjan Sheibani Abdolyousefi, Raham Bahmani Sangesari, Nahid Ashrafi   +2 more
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Uniformities and covering properties for partial frames (I) [PDF]

Categories and General Algebraic Structures with Applications, 2014
Partial frames provide a rich context in which to do pointfree structured and unstructured topology. A small collection of axioms of an elementary nature allows one to do much traditional pointfree topology, both on the level of frames or locales, and ...
John Frith, Anneliese Schauerte
doaj