Results 61 to 70 of about 551,541 (325)
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Some Properties of Brzozowski Derivatives of Regular Expressions [PDF]
arXiv, 2014 Brzozowski derivatives of a regular expression are developed for constructing deterministic automata from the given regular expression in the algebraic way. In this paper,some lemmas of the regular expressions are discussed and the regular languages of the derivatives are illustrated. Also the generalizations of the Brzozowski derivatives are proved as
arxiv
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Symbolic Solving of Extended Regular Expression Inequalities [PDF]
arXiv, 2014 This paper presents a new solution to the containment problem for extended regular expressions that extends basic regular expressions with intersection and complement operators and consider regular expressions on infinite alphabets based on potentially infinite character sets.
arxiv
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Succinctness of the Complement and Intersection of Regular Expressions [PDF]
Dans Proceedings of the 25th Annual Symposium on the Theoretical
Aspects of Computer Science - STACS 2008, Bordeaux : France (2008), 2008 We study the succinctness of the complement and intersection of regular expressions. In particular, we show that when constructing a regular expression defining the complement of a given regular expression, a double exponential size increase cannot be avoided. Similarly, when constructing a regular expression defining the intersection of a fixed and an
arxiv
On the Uniform Distribution of Regular Expressions [PDF]
arXiv, 2021 Although regular expressions do not correspond univocally to regular languages, it is still worthwhile to study their properties and algorithms. For the average case analysis one often relies on the uniform random generation using a specific grammar for regular expressions, that can represent regular languages with more or less redundancy.
arxiv
On the Expressive Power of Regular Expressions with Backreferences
, 2023 20 pages, the full version of the paper to appear in MFCS ...
Nogami, Taisei, Terauchi, Tachio
openaire +4 more sources