Results 41 to 50 of about 7,066,247 (260)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
One the P-Adic Local Invariant Cycle Theorem [PDF]
, 2012 The aim of this paper is to consider the $p$-adic local invariant cycle theorem in the mixed characteristic case. In the first part of the paper, via case-by-case discussion, we construct the $p$-adic specialization map, and then write out the ...
Wu, Yi-Tao
core +1 more source
On the Finiteness Properties of Local Cohomology Modules for Regular Local Rings [PDF]
Tokyo Journal of Mathematics, 2017 13 pages, To appear in Tokyo Journal of ...
SEDGHI, Monireh +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Chern classes in equivariant bordism
Forum of Mathematics, SigmaWe introduce Chern classes in $U(m)$ -equivariant homotopical bordism that refine the Conner–Floyd–Chern classes in the $\mathbf {MU}$ -cohomology of $B U(m)$ .
Stefan Schwede
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Differential Basis and p-Basis of a Regular Local Ring [PDF]
Proceedings of the American Mathematical Society, 1984 We prove that any differential basis of a regular local ring R R of characteristic
Kimura, Tetsuzo, Niitsuma, Hiroshi
openaire +2 more sources
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 1970 The theory of near-rings has arisen in a variety of ways. There is a natural desire to generalise the theory of rings and skew fields by relaxing some of their defining axioms.
Holcombe, William Michael Lloyd
core +5 more sources