Results 51 to 60 of about 2,277,693 (344)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Characterization of self-adjoint domains for regular even order $C$-symmetric differential operators

Electronic Journal of Qualitative Theory of Differential Equations, 2019
Let $C$ be a skew-diagonal constant matrix satisfying $C^{-1}=-C=C^{\ast}$. We characterize the self-adjoint domains for regular even order $C$-symmetric differential operators with two-point boundary conditions. Thepreviously known characterizations are
Jiong Sun, Qinglan Bao, Xiaoling Hao, Anton Zettl   +3 more
doaj   +1 more source

The Arithmetic Operator of Fuzzy Regular Prismoid Numbers and Its Application to Fuzzy Risk Analysis

International Journal of Computational Intelligence Systems, 2021
We devote to study the arithmetic operator of fuzzy regular prismoid numbers as well as the degree of similarity between fuzzy regular prismoid numbers, and then the arithmetic operator and the degree of similarity are applied in risk analysis.
Shexiang Hai
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Regularity for Eigenfunctions of Schrödinger Operators [PDF]

Letters in Mathematical Physics, 2012
We prove a regularity result in weighted Sobolev spaces (or Babuska--Kondratiev spaces) for the eigenfunctions of a Schr dinger operator. More precisely, let K_{a}^{m}(\mathbb{R}^{3N}) be the weighted Sobolev space obtained by blowing up the set of singular points of the Coulomb type potential V(x) = \sum_{1 \le j \le N} \frac{b_j}{|x_j|} + \sum_{1 ...
Nistor, Victor, Ammann, Bernd, Carvalho, Catarina   +2 more
openaire   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Matrix Regular Operator Spaces

Journal of Functional Analysis, 1998
A norm on an ordered real Banach space \(E\) is called regular (or Riesz norm) if \(-x\leq y\leq x\) implies \(\| y\|\leq\| x\|\), and \(\| y\|< 1\) implies the existence of \(x\in E\) with \(\| x\|< 1\) and \(-x\leq y\leq x\). This concept is generalized to matrix ordered complex operator spaces [as introduced by \textit{M.-D. Choi} and \textit{E.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On the Spectra of One-Dimensional Schrödinger Operators With Singular Potentials

Frontiers in Physics, 2019
The paper is devoted to the spectral properties of one-dimensional Schrödinger operators (1)Squ(x)=(-d2dx2+q(x))u(x),    x∈ℝ, with potentials q = q0+qs, where q0∈L∞(ℝ) is a regular potential, and qs∈D′(ℝ) is a singular potential with support on a ...
Vladimir S. Rabinovich, Víctor Barrera-Figueroa, Leticia Olivera Ramírez   +2 more
doaj   +1 more source