Results 101 to 110 of about 398,282 (297)

Gaussian Tests of "Extremal White Noise" for Dependent, Heterogeneous, Heavy Tailed Strochastic Processes with an Application [PDF]

We develop a non-parametric test of tail-specific extremal serial dependence for possibly heavy-tailed time series. The test statistic is asymptotically chi-squared under a null of "extremal white noise", as long as extremes of the time series are Near ...
Jonathan B. Hill
core  

Beyond Lebesgue and Baire: generic regular variation [PDF]

, 2007
We show that the No Trumps combinatorial property (NT), introduced for the study of the foundations of regular variation in LSE-CDAM-2006-22, permits a natural extension of the definition of the class of functions of regular variation, including the ...
Ostaszewski, Adam, Bingham, N. H.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Acute effects of electronic cigarette smoking on heart rate variability

Studia Universitatis Babeș-Bolyai. Biologia, 2017
Heart rate variability (HRV) refers to a temporal variation between consecutive heart beats and is considered a measure of the balance between the sympathetic and the parasympathetic nervous system.
Ștefan-Claudiu MIRESCU, Beatrice Andreea CAITAS, Sergiu HOLHOȘ, Corneliu TARBA, Leontin DAVID   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Kernel Methods for Small Sample and Asymptotic Tail Inference for Dependent, Heterogeneous Data [PDF]

This paper considers tail shape inference techniques robust to substantial degrees of serial dependence and heterogeneity. We detail a new kernel estimator of the asymptotic variance and the exact small sample mean-squared-error, and a simple ...
Jonathan Hill
core  

Regularized Stein Variational Gradient Flow

Foundations of Computational Mathematics
Abstract The stein variational gradient descent (SVGD) algorithm is a deterministic particle method for sampling. However, a mean-field analysis reveals that the gradient flow corresponding to the SVGD algorithm (i.e., the Stein Variational Gradient Flow) only provides a constant-order approximation to the Wasserstein gradient flow ...
Ye He 0003, Krishnakumar Balasubramanian 0002, Bharath K. Sriperumbudur, Jianfeng Lu 0001   +3 more
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Von mises-type conditions in second order regular variation [PDF]

, 1996
We give a thorough treatment concerning sufficient conditions involving derivatives for extended regular variation of second order. Most of the results are new.
Haan, L.F.M. (Laurens) de, de Haan, L., de Haan, Laurens   +2 more
core   +1 more source

Boundary blow-up solutions to semilinear elliptic equations with nonlinear gradient terms

Electronic Journal of Differential Equations, 2014
In this article we study the blow-up rate of solutions near the boundary for the semilinear elliptic problem $$\displaylines{ \Delta u\pm |\nabla u|^q=b(x)f(u), \quad x\in\Omega,\cr u(x)=\infty, \quad x\in\partial\Omega, }$$ where $\Omega$ is a ...
Shufang Liu, Yonglin Xu
doaj