Results 31 to 40 of about 2,384,756 (227)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Numerical Study on the Influence of Interceptor and Stern Flap on Ship Resistance and Motion Response in Regular Waves

Journal of Marine Science and Engineering
Stern flaps and interceptors are prevalent stern appendages on medium- to high-speed ships, designed to modify the sailing posture of ships and diminish resistance.
Kewei Song, Jie Gong, Jincun Ma, Qiang Xu, Yue Shi, Feng Xu   +5 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Numerical simulations of the group effect of large-diameter columns in regular waves

Shuili Shuiyun Gongcheng Xuebao, 2020
Structures with multiple columns are widely used in ocean engineering, and wave loads on large-diameter columns in a group are quite different from the isolated ones. In the present study, a three dimensional hydrodynamic code DIFFRACT based on potential
GAN Guixuan, SUN Liang, YUE Lei, HAN Songlin   +3 more
doaj   +1 more source

Motion of Floating Caisson with Extended Bottom Slab under Regular and Irregular Waves

Journal of Marine Science and Engineering, 2021
Floating caissons may oscillate primarily due to ocean waves during towing operations. Reducing the oscillation based on the extension part (footing) of the bottom slab of the caissons can efficiently increase the safety of towing maneuvers. However, the
Tomoaki Nakamura, Naoto Nagayama, Yong-Hwan Cho, Norimi Mizutani, Yoshinosuke Kurahara, Masahide Takeda   +5 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Influence of interceptor on ship resistance and motion characteristics in regular waves

Zhongguo Jianchuan Yanjiu
ObjectivesThis study analyzes the influence of interceptors on the resistance and motion characteristics of ships in regular waves.MethodsTaking a semi-displacement ship as the research object, the numerical simulation of its resistance and motion ...
Kewei SONG, Jie GONG, Haiyan YANG, Shenwei GE   +3 more
doaj   +1 more source

Numerical simulation of regular wave transmission coefficient over submerged breakwater

Shuili Shuiyun Gongcheng Xuebao, 2017
Wave transmission coefficient over a submerged breakwater is the main index to measure the wave weakened capacity of the submerged breakwater. A numerical wave flume is established by the MIKE21-BW model based on Boussinesq-type equations, and a ...
PAN Dongdong, HAO Jialing, WANG Hongchuan   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source