Results 81 to 90 of about 832,966 (358)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Temporal Graphs and Temporal Network Characteristics for Bio-Inspired Networks during Optimization

Applied Sciences, 2022
Temporal network analysis and time evolution of network characteristics are powerful tools in describing the changing topology of dynamic networks. This paper uses such approaches to better visualize and provide analytical measures for the changes in ...
Nicholas S. DiBrita, Khouloud Eledlebi, Hanno Hildmann, Lucas Culley, A. F. Isakovic   +4 more
doaj   +1 more source

Boundary regularity for $p$-harmonic functions and solutions of obstacle problems on unbounded sets in metric spaces

, 2019
The theory of boundary regularity for $p$-harmonic functions is extended to unbounded open sets in complete metric spaces with a doubling measure supporting a $p$-Poincar\'e inequality ...
Björn, Anders, Hansevi, Daniel
core   +1 more source

Variability in Regularity: Mining Temporal Mobility Patterns in London, Singapore and Beijing Using Smart-Card Data

PLoS ONE, 2016
To discover regularities in human mobility is of fundamental importance to our understanding of urban dynamics, and essential to city and transport planning, urban management and policymaking.
Chen Zhong, M. Batty, E. Manley, Jiaqiu Wang, Zi-jia Wang, Feng Chen, G. Schmitt   +6 more
semanticscholar   +1 more source

Regular subgraphs of almost regular graphs [PDF]

Journal of Combinatorial Theory, Series B, 1984
AbstractSuppose every vertex of a graph G has degree k or k + 1 and at least one vertex has degree k + 1. It is shown that if k ≥ 2q − 2 and q is a prime power then G contains a q-regular subgraph (and hence an r-regular subgraph for all r < q, r ≡ q (mod 2)). It is also proved that every simple graph with maximal degree Δ ≥ 2q − 2 and average degree d
Noga Alon, Gil Kalai, Shmuel Friedland
openaire   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Using Bidimensional Multiscale Entropy Analysis of Ultrasound Images to Assess the Effect of Various Walking Intensities on Plantar Soft Tissues

Entropy, 2021
Walking performance is usually assessed by linear analysis of walking outcome measures. However, human movements consist of both linear and nonlinear complexity components. The purpose of this study was to use bidimensional multiscale entropy analysis of
Ben-Yi Liau, Fu-Lien Wu, Keying Zhang, Chi-Wen Lung, Chunmei Cao, Yih-Kuen Jan   +5 more
doaj   +1 more source

Non-Autonomous Maximal Regularity in Hilbert Spaces

, 2016
We consider non-autonomous evolutionary problems of the form $u'(t)+A(t)u(t)=f(t)$, $u(0)=u_0,$ on $L^2([0,T];H)$, where $H$ is a Hilbert space.
Dier, Dominik, Zacher, Rico
core   +1 more source

Regular factors in nearly regular graphs

Discrete Mathematics, 1984
AbstractWe strengthen classical theorems of Petersen, Ore, Bäbler, Gallai on the existence of regular factors in regular graphs to nearly regular graphs.
Bermond, Jean-Claude, Las Vergnas, Michel   +1 more
openaire   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source