Results 41 to 50 of about 58,601 (260)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

An Adaptive Parameter Estimation in a BTV Regularized Image Super-Resolution Reconstruction

Advances in Electrical and Computer Engineering, 2017
Access to the fine spatial resolution has always been a hotspot in digital imaging. One way to improve resolution is to use signal post-processing techniques. In this study, an improved multi-frame image super-resolution (SR) algorithm is proposed. The
MOFIDI, M., HAJGHASSEM, H., AFIFI, A.
doaj   +1 more source

Evaluation of Fifteen Algorithms for the Resolution of the Electrocardiography Imaging Inverse Problem Using ex-vivo and in-silico Data

Frontiers in Physiology, 2018
The electrocardiographic imaging inverse problem is ill-posed. Regularization has to be applied to stabilize the problem and solve for a realistic solution. Here, we assess different regularization methods for solving the inverse problem.
Amel Karoui, Amel Karoui, Amel Karoui, Laura Bear, Pauline Migerditichan, Pauline Migerditichan, Nejib Zemzemi, Nejib Zemzemi, Nejib Zemzemi   +8 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Optimal error bound and modified kernel method for a space-fractional backward diffusion problem

Advances in Difference Equations, 2018
In this paper, we consider a backward problem for a space-fractional diffusion equation. This problem is ill-posed, i.e., the solution does not depend continuously on the data. The optimal error bound for the problem under a source condition is analyzed.
Songshu Liu, Lixin Feng
doaj   +1 more source

A Note on Estimating the Optimal Regularization Parameter [PDF]

SIAM Journal on Numerical Analysis, 1980
The behavior of a quantity which in some cases permits the approximation of the optimal regularization parameter is examined. A previously considered numerical example is shown to conform to theory.
openaire   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

The Truncation Regularization Method for Identifying the Initial Value on Non-Homogeneous Time-Fractional Diffusion-Wave Equations

Mathematics, 2019
In the essay, we consider an initial value question for a mixed initial-boundary value of time-fractional diffusion-wave equations. This matter is an ill-posed problem; the solution relies discontinuously on the measured information.
Fan Yang, Qu Pu, Xiao-Xiao Li, Dun-Gang Li   +3 more
doaj   +1 more source

Multiparametric Identification of Several Thermophysical Characteristics by Solving the Internal Inverse Heat Conduction Problem [PDF]

Journal of Mechanical Engineering, 2020
Approaches to the identification of thermophysical characteristics, using methods for solving inverse heat conduction problems and A. N. Tikhonov’s regularization method, are developed.
Yurii M. Matsevytyi, Valerii V. Hanchyn
doaj   +1 more source

Regular Inference for State Machines with Parameters [PDF]

, 2006
Techniques for inferring a regular language, in the form of a finite automaton, from a sufficiently large sample of accepted and nonaccepted input words, have been employed to construct models of software and hardware systems, for use, e.g., in test case generation.
Therese Berg, Bengt Jonsson 0001, Harald Raffelt   +2 more
openaire   +1 more source