Results 91 to 100 of about 2,593,342 (293)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Regulating algorithmic filtering on social media [PDF]
arXiv, 2020 By filtering the content that users see, social media platforms have the ability to influence users' perceptions and decisions, from their dining choices to their voting preferences. This influence has drawn scrutiny, with many calling for regulations on filtering algorithms, but designing and enforcing regulations remains challenging. In this work, we
arxiv
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
Nature Communications, 2020 ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren +11 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Regulating the $P^+ = 0$ Singularity [PDF]
arXiv, 2000 I shall discuss the regulation of the $P^+ = 0$ singularity and give some examples. Regulating the singularity induces new operators into the theory. This process seems rather different for the case of ultraviolet singularities than for the case of infrared singularities.
arxiv
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
On the regulator of Fermat motives and generalized hypergeometric functions [PDF]
arXiv, 2009 We calculate the Beilinson regulators of motives associated to Fermat curves and express them by special values of generalized hypergeometric functions. As a result, we obtain surjectivity results of the regulator, which support the Beilinson conjecture on special values of L-functions.
arxiv
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
A rigid analytical regulator for the K_2 of Mumford curves [PDF]
arXiv, 2009 We construct a rigid analytical regulator for the K_2 of Mumford curves, a non-archimedean analogue of the complex analytical Beilinson-Bloch-Deligne regulator.
arxiv