Results 71 to 80 of about 4,476,518 (315)

Isoform switching facilitates period control in the Neurospora crassa circadian clock

open access: yesMolecular Systems Biology, 2008
A striking and defining feature of circadian clocks is the small variation in period over a physiological range of temperatures. This is referred to as temperature compensation, although recent work has suggested that the variation observed is a specific,
Ozgur E Akman   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Stricter regulation boosts exports: the case of Maximum Residue Levels in pesticides [PDF]

open access: yes, 2014
Constructing an original panel on Maximum Residue Levels (MRLs) in pesticides for 50 countries over 2006-2012, this paper studies the effect of heterogeneity in MRL regulation on bilateral trade.
Foletti, Liliana, Shingal, Anirudh
core  

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

open access: yesNature Communications
Actin cytoskeleton dynamics is essential for proper nervous system development and function. A conserved set of neuronal-specific microexons influences multiple aspects of neurobiology; however, their roles in regulating the actin cytoskeleton are ...
Patryk Poliński   +31 more
doaj   +1 more source

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement

open access: yesReproductive Biology and Endocrinology, 2018
Background LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well as metabolic abnormalities.
Xiaoyu Tu   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Contractual Landmines

open access: yes
This page contains the code and data necessary to replicate the results of "Contractual Landmines" by Robert E. Scott, Stephen J. Choi, & Mitu Gulati, published in the Yale Journal on Regulation (2024)
Journal on Regulation, Yale
core   +1 more source

International Regulation of Emerging Technologies: Global Ideologies and Local Headaches [PDF]

open access: yes, 2016
This paper begins to address the international regulation of emerging technologies taking an approach that includes the co-production of technologies and the nature of wicked problems.
Jost, Dannie
core  

Oregon Division of Financial Regulation consumer advocates

open access: yes, 2022
Do you have finance or insurance questions? The Oregon Insurance Commissioner's team of experts are available to help. Contact the Oregon Department of Financial Regulation for both financial services and insurance (including health, auto, and home ...

core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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