Results 121 to 130 of about 4,476,518 (315)

Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice

Biology of Sex Differences
Background The circadian clock integrates external environmental changes into the internal physiology of organisms. Perturbed circadian clocks due to misaligned light cycles increase the risk of diseases, including metabolic disorders.
Tiantian Ma, Ryohei Matsuo, Kaito Kurogi, Shunsuke Miyamoto, Tatsumi Morita, Marina Shinozuka, Fuka Taniguchi, Keisuke Ikegami, Shinobu Yasuo   +8 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Report on the World Dialogue on Regulation : diversifying participation in network development

, 2007
The World Dialogue on Regulation (WDR) facilitates dialogue to generate and disseminate new knowledge on frontier issues in regulation and governance to support the development of network economies.
World Dialogue on Regulation for Network Economies (WDR)
core  

Regulating the regulators

Journal of Experimental Medicine, 2009
Co-culture of PD-L1–expressing beads (red) and naive T cells (purple) promotes their conversion into T reg cells (green).
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Publication of general insurance statistics [PDF]

, 2016
The Australian Prudential Regulation Authority (APRA) today released a discussion paper on proposed changes to its general insurance statistical publications. APRA proposes to publish more general insurance statistics, including data recently determined
Australian Prudential Regulation Authority (APRA)
core  

Biosynthetic gene clusters from uncultivated soil bacteria of the Atacama Desert

mSphere
Soil microorganisms mediate several biological processes through the secretion of natural products synthesized in specialized metabolic pathways, yet functional characterization in ecological contexts remains challenging.
Constanza M. Andreani-Gerard, Verónica Cambiazo, Mauricio González   +2 more
doaj   +1 more source

Regulate or Be Regulated

Texas A&M Journal of Property Law, 2018
In most states, the landman profession is unregulated and free to define itself. Work performed by landmen often flirts with the practice of law, but under Texas law much of the work that landmen perform is excepted from the unlicensed practice of law.
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Risk Perceptions in Regulation, Tort Liability, and the Market

, 1991
article published in a journal of administrative lawRisk regulations are generally based on a stylized view of the behavior of the individuals affected by the regulation.
Viscusi, W. Kip
core   +1 more source