Results 141 to 150 of about 8,386,993 (362)
State Regulation of the Securities of Railroads and Public Service Companies 1 [PDF]
Mary L. Barron
openalex +1 more source
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini+10 more
wiley +1 more source
Motives for exercise participation as predictors of exercise dependence among endurance athletes [PDF]
Background. To investigate whether motives for exercise participation predicted exercise dependence (ED) among endurance athletes. The rationale for the study centred upon a test of the affect regulation model utilising constructs that form part of the ...
Hamer, M+2 more
core
Biosynthetic gene clusters from uncultivated soil bacteria of the Atacama Desert
Soil microorganisms mediate several biological processes through the secretion of natural products synthesized in specialized metabolic pathways, yet functional characterization in ecological contexts remains challenging.
Constanza M. Andreani-Gerard+2 more
doaj +1 more source
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan+10 more
wiley +1 more source
Neural correlates of early deliberate emotion regulation: Young children\u27s responses to interpersonal scaffolding. [PDF]
Deliberate emotion regulation, the ability to willfully modulate emotional experiences, is shaped through interpersonal scaffolding and forecasts later functioning in multiple domains.
Fishburn, Frank A+7 more
core +1 more source
METABOLIC PATTERNS DURING PHYSIOLOGIC SLEEP: I. BLOOD GLUCOSE REGULATION DURING SLEEP IN NORMAL AND DIABETIC SUBJECTS* [PDF]
Eugene D. Robin+3 more
openalex +1 more source
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim+8 more
wiley +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu+15 more
wiley +1 more source