Results 81 to 90 of about 8,386,993 (362)

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

open access: yesNature Communications
Actin cytoskeleton dynamics is essential for proper nervous system development and function. A conserved set of neuronal-specific microexons influences multiple aspects of neurobiology; however, their roles in regulating the actin cytoskeleton are ...
Patryk Poliński   +31 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Capitalisme politique et développement dépendant en Asie du Sud-Est [PDF]

open access: yes, 2007
Les États « très en retard » de développement se caractérisent par de nombreuses dépendances : la forme autoritaire de la domination politique sous l’autorité des clans ; des politiques de concessions aux affidés ; une faible diversification de leur ...
Bafoil, François
core   +1 more source

Nationwide safety surveillance of COVID-19 mRNA vaccines following primary series and first booster vaccination in Singapore

open access: yesVaccine: X, 2023
Background: The real-world safety profile of COVID-19 mRNA vaccines remains incompletely elucidated. Methods: We performed a nationwide post-market safety surveillance analysis in Singapore, on vacinees aged 5 years and older, through mid-September 2022.
Sreemanee Raaj Dorajoo   +15 more
doaj  

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement

open access: yesReproductive Biology and Endocrinology, 2018
Background LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well as metabolic abnormalities.
Xiaoyu Tu   +6 more
doaj   +1 more source

COLLABORATIVE REGULATION

open access: yesLaw, State and Telecommunications Review, 2021
Purpose - The purpose of this paper is to analyze in theory and practice the extent and ways the role of regulators in collaborative regulatory systems differs from their roles in more traditional, state-led regulatory systems. Methodology/Approach/Design - The descriptive and analytical methodology of this paper is supported by primary and ...
openaire   +4 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Not all financial regulation is global [PDF]

open access: yes
Financial regulation at global level has been high on the G20 agenda. However, financial multipolarity, with the rise of emerging economies, and its impact on decision-making at global level has made global convergence difficult.
Nicolas Véron, Stephane Rottier
core   +1 more source

Regulating Disruption: Blockchain, GDPR, and Questions of Data Sovereignty [PDF]

open access: yes, 2018
The article discusses the nature of law in cyberspace. Topics discussed include distinction between regulation as infringement of private autonomy and regulation as a collaborative enterprise; blockchain regulatory conundrum; and neoliberal market ...
Herian, Robert
core  

'Maybe they should regulate them quite strictly until they know the true dangers': A focus group study exploring UK adolescents’ views on e-cigarette regulation [PDF]

open access: yes, 2016
Background and aims: Regulation of electronic cigarettes has moved to the top of the addiction policy agenda, as demonstrated by the recent focus across the UK on introducing age of sale restrictions.
Hilton, Shona   +2 more
core   +1 more source

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