Results 221 to 230 of about 35,903 (275)

Bimekizumab efficacy using IHS4 outcomes in hidradenitis suppurativa: Results from BE HEARD I and II

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The majority of bimekizumab‐treated patients shifted from severe to mild and moderate IHS4 stages, and nearly 25% achieved an IHS4 of 0 by Week 48. Bimekizumab led to clinically meaningful improvements across IHS4 outcome measures. These data highlight an opportunity to address the need for effective treatments against draining tunnels.
Thrasyvoulos Tzellos, Evangelos J. Giamarellos‐Bourboulis, Kelsey R. van Straalen, Antonio Martorell, Brian Kirby, Afsaneh Alavi, Koremasa Hayama, Saakshi Khattri, Wayne Gulliver, Christopher J. Sayed, Leah Davis, Robert L. Rolleri, Christina Crater, Ingrid Pansar, Jérémy Lambert, Christos C. Zouboulis   +15 more
wiley   +1 more source

Molecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function. [PDF]

Nat Commun
Csoma N, Machin JM, Whitehouse JM, Rodrìguez-Alonso R, Olejnik M, Cahill AK, Cho SH, Schäberle TF, Iorga BI, Ranson NA, Radford SE, Calabrese AN, Collet JF.   +12 more
europepmc   +1 more source

Asian bond markets: issues and prospects [PDF]

Bank for International Settlements, Changyong Rhee, Daekeun Park   +2 more
core  

Frequency of arboreality is correlated with longer hand skeletons in Gorilla: Analysis of a new skeletal sample of Bwindi mountain gorillas

Journal of Anatomy, EarlyView.
Variation in arboreality across gorilla populations is associated with systematic differences in manual digital lengths. Using a new dataset of linear metrics from the Bwindi mountain gorillas, we quantify metacarpal and phalangeal lengths in eastern and western gorilla populations across all five rays. Consistent with quantified behavioral differences,
Elliot G. Greiner, Christopher B. Ruff, Charlotte King, Aventino Nkwasibwe, Thadee Muhire, Emmanuel Tibenda, Jason S. Massey, Juho‐Antti Junno, Rowan M. Sherwood, Jean Bosco Noheri, Fred Nizeyimana, Tierra Smiley Evans, Richard Muvunyi, Dennis Babaasa, Martha M. Robbins, Shannon C. McFarlin, Tracy L. Kivell   +16 more
wiley   +1 more source

“Design principles of a membrane-spanning ubiquitin ligase”

Williams C, Nocka LM, Hedger G, Parashara P, Pardon E, Latorraca NR, Pusapati GV, Lartey D, Gao L, Milenkovic L, Chalk R, Steyaert J, Marqusee S, Carrique L, Bazan JF, Rouse SL, Kong JH, Siebold C, Rohatgi R.   +18 more
europepmc   +1 more source

Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers. [PDF]

Breast Cancer Res
Derouane F, Desgres M, Moroni C, Ambroise J, Berlière M, Van Bockstal MR, Galant C, van Marcke C, Vara-Messler M, Hutten SJ, Jonkers J, Mourao L, Scheele CLGJ, Duhoux FP, Corbet C.   +14 more
europepmc   +1 more source

MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma. [PDF]

Cell Rep
Dias D, Oliveira E, Martí-Díaz R, Andrews S, Chocarro-Calvo A, Bellini A, Mosteo L, García YV, Chauhan J, Li L, García-Martinez JM, Rodriguez-López JN, Maria-Engler SS, Kenny C, Martínez-Useros J, García-Jiménez C, Sanchez-Del-Campo L, Louphrasitthiphol P, Goding CR.   +18 more
europepmc   +1 more source

Vacuolar-type H⁺-ATPase-mediated extra-organellar buffering resolves mitochondrial dysfunction. [PDF]

Nat Commun
Monteuuis G, Awadhpersad R, van der Kolk D, Singh SK, Nyman TA, Malyutina A, Zamboni N, Moisio K, Juutila J, Hietakangas V, Seneca S, Carroll CJ, Jackson CB.   +12 more
europepmc   +1 more source

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody. [PDF]

Elife
Pinto Torres JE, Claes M, Hendrickx R, Yuan M, Smiejkowska N, Van Wielendaele P, Hacisuleyman A, De Winter H, Muyldermans S, Michels PAM, Walkinshaw MD, Versées W, Caljon G, Magez S, Sterckx YG.   +14 more
europepmc   +1 more source