Results 1 to 10 of about 40,003 (70)
An emergency brake for protein synthesis
eLife, 2017 The integrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.
Vladislava Hronová +1 more
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Nature Communications, 2021 A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-20927-9.
Keito Okazaki +20 more
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KDM2 Family Members are Regulated by HIF-1 in Hypoxia
Cells, 2017 Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF).
Michael Batie +3 more
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npj Aging and Mechanisms of Disease, 2020 Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to pathogenesis of
Tetsuya Oishi +7 more
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Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC
eLife, 2018 We describe Ribo Mega-SEC, a powerful approach for the separation and biochemical analysis of mammalian polysomes and ribosomal subunits using Size Exclusion Chromatography and uHPLC.
Harunori Yoshikawa +6 more
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LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
Nature Communications, 2018 Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously ...
Ye Hong +9 more
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The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II
Cell Reports, 2018 Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear cell
Marco Trizzino +8 more
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Redox Biology, 2020 Saliva plays an essential role in the maintenance of oral health. The oral cavity environment changes during aging mainly due to alterations in the secretion and composition of saliva.
Sisca Meida Wati +2 more
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Molecular Therapy: Nucleic Acids, 2017 RNAi has been suggested for use in gene therapy of HIV/AIDS, but the main problem is that HIV-1 is highly variable and could escape attack from the small interfering RNAs (siRNAs) due to even single nucleotide substitutions in the potential targets.
Olga V. Kretova +8 more
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