Results 31 to 40 of about 2,720,747 (207)

Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways. [PDF]

, 2014
Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related ...
Attardo, Geoffrey M, Drake, Lisa L, Hansen, Immo A, Rodriguez, Stacy D   +3 more
core   +2 more sources

Efficient and Rapid Analysis of Polysomes and Ribosomal Subunits in Cells and Tissues Using Ribo Mega-SEC

Bio-Protocol, 2021
Polysome profile analysis is a popular method for separating polysomes and ribosomal subunits and is typically achieved using a sucrose density gradient (SDG).
Harunori Yoshikawa, Ramasubramanian Sundaramoorthy, Daniel Mariyappa, Hao Jiang, Angus Lamond   +4 more
doaj   +1 more source

Origins of Binary Gene Expression in Post-transcriptional Regulation by MicroRNAs

, 2012
MicroRNA-mediated regulation of gene expression is characterised by some distinctive features that set it apart from unregulated and transcription factor-regulated gene expression. Recently, a mathematical model has been proposed to describe the dynamics
Bose, Indrani, Ghosh, Sayantari
core   +1 more source

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

ARID1A promotes genomic stability through protecting telomere cohesion

Nature Communications, 2019
Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in
Bo Zhao, Jianhuang Lin, Lijie Rong, Shuai Wu, Zhong Deng, Nail Fatkhutdinov, Joseph Zundell, Takeshi Fukumoto, Qin Liu, Andrew Kossenkov, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Ronny Drapkin, Paul M. Lieberman, Cory T. Abate-Shen, Rugang Zhang   +16 more
doaj   +1 more source

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Molecular Medicine, 2020
The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania.
Anna E. Pravednikova, Sergey Y. Shevchenko, Victor V. Kerchev, Manana R. Skhirtladze, Svetlana N. Larina, Zaur M. Kachaev, Alexander D. Egorov, Yulii V. Shidlovskii   +7 more
doaj   +1 more source

Administration of Insurance Rate Regulatory Laws [PDF]

, 1950
microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was
Ernberg, Ingemar, Grigorieva, Elvira V, Kashuba, Vladimir I, Mostovich, Luydmila A, Prudnikova, Tatiana Y, Zabarovsky, Eugene R   +5 more
core   +3 more sources

BCL7A is silenced by hypermethylation to promote acute myeloid leukemia

Biomarker Research, 2023
Background Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood.
Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros, Pedro P. Medina   +8 more
doaj   +1 more source

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

Cell Reports, 2017
Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not ...
Robert C. Alver, Gaganmeet Singh Chadha, Peter J. Gillespie, J. Julian Blow   +3 more
doaj   +1 more source

Optimising the IgG‐degrading enzyme treatment regimen for enhanced adeno‐associated virus transduction in the presence of neutralising antibodies

Clinical & Translational Immunology, 2022
Objective Pre‐existing neutralising antibodies (NAbs) to adeno‐associated viruses (AAVs) remain an impediment for systemically administered AAV‐mediated gene therapy treatment in many patients, and various strategies are under investigation to overcome ...
Irene Ros‐Gañán, Mirja Hommel, Laia Trigueros‐Motos, Blanche Tamarit, Estefanía Rodríguez‐García, David Salas, Guiomar Pérez, Anne Douar, Jean Philippe Combal, Bernard Benichou, Veronica Ferrer, Gloria González‐Aseguinolaza   +11 more
doaj   +1 more source