Results 51 to 60 of about 175,401,209 (303)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

Nature Communications, 2018
CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor ...
Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang   +14 more
doaj   +1 more source

Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice

BMC Genomics, 2018
Background Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood.
Nikita I. Ershov, Natalya P. Bondar, Arina A. Lepeshko, Vasiliy V. Reshetnikov, Julia A. Ryabushkina, Tatiana I. Merkulova   +5 more
doaj   +1 more source

ISR8/IRF1-AS1 Is Relevant for IFNα and NF-κB Responses

Frontiers in Immunology, 2022
The study of the interferon (IFN) α-induced cell transcriptome has shown altered expression of several long non-coding RNAs (lncRNAs). ISR8/IRF1-AS1 (IFN stimulated RNA 8), located close to IFN regulatory factor 1 (IRF1) coding gene, transcribes a lncRNA
Marina Barriocanal, Laura Prats-Mari, Nerea Razquin, Celia Prior, Juan Pablo Unfried, Puri Fortes, Puri Fortes, Puri Fortes, Puri Fortes   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells [PDF]

, 2014
Cells transform external stimuli, through the activation of signaling pathways, which in turn activate gene regulatory networks, in gene expression. As more omics data are generated from experiments, eliciting the integrated relationship between the ...
den Breems, NY, den Breems, Nicoline Y., Kulasiri, Don, Nguyen, LK, Nguyen, Lan K.   +4 more
core   +1 more source

Dualistic role of ZEB1 and ZEB2 in tumor progression

Biology Direct
It is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev, Alexandra A. Daks, Oleg Y. Shuvalov, Olga A. Fedorova, Nikolay B. Pestov, Tatyana V. Korneenko, Nickolai A. Barlev   +6 more
doaj   +1 more source

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Nature Communications, 2019
Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber, Leticia Odriozola, Javier Martínez-García, Veronica Ferrer, Anne Douar, Bernard Bénichou, Gloria González-Aseguinolaza, Cristian Smerdou   +7 more
doaj   +1 more source

Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells

eLife, 2015
Previously, we analyzed protein abundance changes across a ‘minimally perturbed’ cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014).
Tony Ly, Aki Endo, Angus I Lamond
doaj   +1 more source

Optimising the IgG‐degrading enzyme treatment regimen for enhanced adeno‐associated virus transduction in the presence of neutralising antibodies

Clinical & Translational Immunology, 2022
Objective Pre‐existing neutralising antibodies (NAbs) to adeno‐associated viruses (AAVs) remain an impediment for systemically administered AAV‐mediated gene therapy treatment in many patients, and various strategies are under investigation to overcome ...
Irene Ros‐Gañán, Mirja Hommel, Laia Trigueros‐Motos, Blanche Tamarit, Estefanía Rodríguez‐García, David Salas, Guiomar Pérez, Anne Douar, Jean Philippe Combal, Bernard Benichou, Veronica Ferrer, Gloria González‐Aseguinolaza   +11 more
doaj   +1 more source