Stochastic modeling of regulation of gene expression by multiple small RNAs
, 2011 A wealth of new research has highlighted the critical roles of small RNAs (sRNAs) in diverse processes such as quorum sensing and cellular responses to stress.
Baker, Charles +2 more
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Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]
, 2018 Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core +2 more sources
Molecular Basis of the Function of Transcriptional Enhancers
Cells, 2020 Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process ...
Airat N. Ibragimov +2 more
doaj +1 more source
Evolution of Regulated Transcription
Cells, 2020 The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and ...
Oleg V. Bylino +2 more
doaj +1 more source
Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. [PDF]
, 2013 Spatial relationships within the eukaryotic nucleus are essential for proper nuclear function. In Plasmodium falciparum, the repositioning of chromosomes has been implicated in the regulation of the expression of genes responsible for antigenic variation,
Berriman, Matthew +8 more
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The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II
Cell Reports, 2018 Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear cell
Marco Trizzino +8 more
doaj +1 more source
Timed and targeted differential regulation of nitric oxide synthase (NOS) and anti-NOS genes by reward conditioning leading to long-term memory formation [PDF]
, 2005 In a number of neuronal models of learning, signaling by the neurotransmitter nitric oxide (NO), synthesized by the enzyme neuronal NO synthase (nNOS), is essential for the formation of long-term memory (LTM). Using the molluscan model system Lymnaea, we
Benjamin, Paul R +6 more
core +1 more source
Cells, 2019 Human rDNA clusters form numerous contacts with different chromosomal regions as evidenced by chromosome conformation capture data. Heterochromatization of rDNA genes leads to heterochromatization in different chromosomal regions coupled with the ...
Nickolai A. Tchurikov +6 more
doaj +1 more source
MiRNA-34 and stress response [PDF]
, 2017 Psychiatric disorders are known to result from a strong interaction between genetic predisposition and environmental factors, mainly exposure to stressful events. Environmental events can modulate genes expression, possibly via epigenetic mechanisms, and
Andolina, Diego +2 more
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ZEB1 protects skeletal muscle from damage and is required for its regeneration
Nature Communications, 2019 Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role ...
Laura Siles +4 more
doaj +1 more source