Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
THE PREDICTION OF SCIENTIFIC-TECHNOLOGICAL DEVELOPMENT OF GRAIN ECONOMY OF THE RUSSIAN FEDERATION
Зерновое хозяйство России, 2018 The article deals with the results of predictions of scientific-technological development of grain economy of the Russian Federation. The results of the study determined that the efficient use of land resources under grain crops could be achieved if the ...
A. N. Tarasov
doaj +2 more sources
Regulating the $P^+ = 0$ Singularity [PDF]
arXiv, 2000 I shall discuss the regulation of the $P^+ = 0$ singularity and give some examples. Regulating the singularity induces new operators into the theory. This process seems rather different for the case of ultraviolet singularities than for the case of infrared singularities.
arxiv
Firm technological responses to regulatory changes: A longitudinal study in the Le Mans Prototype racing [PDF]
, 2018 Despite the critical role of regulations on competition and innovation, little is known about firm responses and related effects on performance under regulatory contingencies that are permissive or restrictive. By longitudinally investigating hybrid cars
Aversa, P., Guillotin, O.
core +1 more source
Developing public health regulations for marijuana: lessons from alcohol and tobacco.
American Journal of Public Health, 2014 Until November 2012, no modern jurisdiction had removed the prohibition on the commercial production, distribution, and sale of marijuana for nonmedical purposes-not even the Netherlands.
R. Pacula +4 more
semanticscholar +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
On the regulator of Fermat motives and generalized hypergeometric functions [PDF]
arXiv, 2009 We calculate the Beilinson regulators of motives associated to Fermat curves and express them by special values of generalized hypergeometric functions. As a result, we obtain surjectivity results of the regulator, which support the Beilinson conjecture on special values of L-functions.
arxiv
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Importance of methodological details in the measurement of cortisol in human hair
Endocrine Regulations, 2018 Objective. The measurement of cortisol in hair became a popular and frequently used methodology in human stress research. This methodological approach, depending on the length of hair analyzed, allows to reflect cortisol secretion over prolong time ...
Balagova Lucia, Jezova Daniela
doaj +1 more source
A rigid analytical regulator for the K_2 of Mumford curves [PDF]
arXiv, 2009 We construct a rigid analytical regulator for the K_2 of Mumford curves, a non-archimedean analogue of the complex analytical Beilinson-Bloch-Deligne regulator.
arxiv