Results 141 to 150 of about 4,194,617 (361)
Institutionalised ignorance in policy and regulation [PDF]
, 2022 Katharina T. Paul +2 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Assessing the impact of amended building regulations on the operations of UK construction companies [PDF]
, 2008 The UK government continues to make regular amendments to building regulations. This is in order to keep these regulations relevant to today’s prevailing construction environment. More recently, UK building regulations have been amended to facilitate the
Dawson, Richard +2 more
core
Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure [PDF]
, 2008 Miguel Pérez Fontán +7 more
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
How to achieve sustainability : regulatory challenges [PDF]
, 2005 The importance of designing sustainable buildings is gaining greater acceptance worldwide. Evidence of this is how regulators are incorporating sustainable design principles into building regulations and requirements.
Ambrose, Michael, Miller, Anne
core +1 more source
NOVA2-mediated RNA regulation is required for axonal pathfinding during development
, 2016 Yuhki Saito +13 more
openalex +1 more source