Results 31 to 40 of about 1,302,388 (314)

SUMO: regulating the regulator.

Cell division, 2006
Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review
Bossis, G., Melchior, F.
openaire   +4 more sources

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Regulations of the Virginia Military Institute, 1931 [PDF]

, 1931
Regulations for the Corps of Cadets of the Virginia Military Institute. These regulations governed all aspects of cadet life.
Virginia Military Institute
core  

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Regulations of the Virginia Military Institute, 1905 [PDF]

, 1905
Regulations for the Corps of Cadets of the Virginia Military Institute. These regulations governed all aspects of cadet life.
Virginia Military Institute
core  

Evidence that tyrosine hydroxylase does not have enzymatic activity in neurons of the supraoptic nucleus

Frontiers in Endocrinology
IntroductionAlthough numerous neurons expressing tyrosine hydroxylase (TH), the first enzyme of catecholamine synthesis, were discovered in the supraoptic nucleus (SON) of hypothalamus in animals almost forty years ago, mainly under osmotic stress, the ...
Tatiana S. Pronina, Dmitry V. Troshev, Anna A. Kolacheva, Vsevolod V. Bogdanov, Michael V. Ugrumov   +4 more
doaj   +1 more source

Regulations of the Virginia Military Institute, 1923 [PDF]

, 1923
Regulations for the Corps of Cadets of the Virginia Military Institute. These regulations governed all aspects of cadet life.
Virginia Military Institute
core  

Hallmarks of nuclear metabolism: implications for genome integrity, nuclear signaling, and therapeutic targeting

npj Metabolic Health and Disease
Certain metabolic enzymes localize to the nucleus, where they perform regulatory functions that extend far beyond canonical metabolism. Once inside, they influence chromatin organization, transcription, DNA repair, and cell cycle progression. This review
Alisa Schmidt, Matilda Pfeiffer, Sara Sdelci   +2 more
doaj   +1 more source

Throttling Growth Speed: Evaluation of aux1-7 Root Growth Profile by Combining D-Root system and Root Penetration Assay

Plants, 2022
Directional root growth control is crucial for plant fitness. The degree of root growth deviation depends on several factors, whereby exogenous growth conditions have a profound impact. The perception of mechanical impedance by wild-type roots results in
Judith García-González, Jozef Lacek, Wolfram Weckwerth, Katarzyna Retzer   +3 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source