Results 61 to 70 of about 1,296,155 (314)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Physician Reported Work-Related COVID-19 cases in Norway 2020 – 2021

open access: yesSafety and Health at Work, 2022
Yogindra Samant   +4 more
doaj   +1 more source

Regulations of the Virginia Military Institute, 1905

open access: yes, 1905
Regulations for the Corps of Cadets of the Virginia Military Institute. These regulations governed all aspects of cadet life.
Virginia Military Institute
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Regulations of the Virginia Military Institute, 1923

open access: yes, 1923
Regulations for the Corps of Cadets of the Virginia Military Institute. These regulations governed all aspects of cadet life.
Virginia Military Institute
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Tyrosine Hydroxylase Expression in Differentiating Neurons of the Rat Arcuate Nucleus: Stimulatory Influence of Serotonin Afferents

open access: yesNeural Plasticity, 2001
The influence of serotonin afferents on tyrosine hydroxylase expression in differentiating neurons of the rat arcuate nucleus was studied in vivo and in vitro.
Viktoria I. Melnikova   +4 more
doaj   +1 more source

The Rise of Technocratic Leadership in the 1990s in the People’s Republic of China

open access: yesPolitics and Governance, 2020
The transformation of China’s political elite provides important insights into the nation’s political metamorphosis and the changes in cadre selection criteria.
Rongrong Lin
doaj   +1 more source

Report of the Regulations Modernization Task Force.

open access: yes, 2013
Pursuant to Public Act 12-92.; "Presented to: Governor Dannel P. Malloy, Legislative Regulations Review Committee."; "February 1, 2013.
Connecticut. Regulations Modernization Task Force,
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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