Results 121 to 130 of about 1,924,997 (302)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Space shuttle OMS helium regulator design and development [PDF]
Analysis, design, fabrication and design verification testing was conducted on the technological feasiblity of the helium pressurization regulator for the space shuttle orbital maneuvering system application.
Kelly, T. L., Lynch, R., Wichmann, H.
core +1 more source
Practical improvements to class group and regulator computation of real quadratic fields [PDF]
, 2010 We present improvements to the index-calculus algorithm for the computation of the ideal class group and regulator of a real quadratic field. Our improvements consist of applying the double large prime strategy, an improved structured Gaussian ...
Biasse, Jean-François +1 more
core +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Self-contained breathing apparatus [PDF]
, 1976 A self-contained breathing apparatus with automatic redundant fluid pressure controls and a facemask mounted low pressure whistle alarm is described. The first stage of the system includes pair of pressure regulators connected in parallel with different ...
Giorgini, E. A. +2 more
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
THE REGULATION OF THE MARKET FOR PHARMACEUTICALS: FOREIGN EXPERIENCE
Модернизация, инновация, развитие, 2015 In article the question of regulation of the market of medicines in approaches of foreign scientists is considered. Three main lines of such regulation are named: the political tasks regulating institutes and ways of regulation, from which tasks and ways
D. L. Grishin
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source