Results 181 to 190 of about 1,314,428 (309)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

miR-10-3p, but not miR-1006-3p, regulates <i>mei-P26</i> expression in the <i>Drosophila</i> testis. [PDF]

MicroPubl Biol
Thangadurai S, Pak E, Hammock I, Murashov A.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Activation of secondary metabolism in <i>Aspergillus</i> and related filamentous fungi through regulatory engineering. [PDF]

RSC Chem Biol
Shyong J, Wang CCC.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

NRS-22340 | Annual reports [Independent Transport Safety and Reliability Regulator / Office of the Independent Transport Safety Regulator]

Annual reports provide an overview of the work of an agency work during the reporting year. Most reporting years are for the financial year ending 30 June, though earlier twentieth century reports may have been for the calendar year ending 31 ...

core  

Splicing time: how WRKY55 isoforms regulate ABA signaling to balance growth and stress responses. [PDF]

Plant Physiol
Gómez-Álvarez EM.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Nutrient-Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus. [PDF]

Mol Microbiol
Adler C, Segal G.
europepmc   +1 more source

Regulating the Regulators [PDF]

, 2015
openaire   +1 more source