Results 231 to 240 of about 1,984,687 (355)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

An artificial intelligence-based approach for identifying the proteins regulating liquid-liquid phase separation. [PDF]

Brief Bioinform
Ahmed Z, Shahzadi K, Li R, Jiang YQ, Jin YT, Arif M, Feng J.   +6 more
europepmc   +1 more source

Genetic Mapping of the phoR Regulator Gene of Alkaline Phosphatase in Escherichia coli

, 1969
Moshe Bracha, Ezra Yagil
openalex   +1 more source

Regulators of cell division in plant tissues [PDF]

, 1969
D. S. Letham
openalex   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

EefR mutations drive sanguinarine resistance by activating cryptic multidrug efflux pumps in AcrB-Null <i>Escherichia coli</i>. [PDF]

Virulence
Shen HJ, Wang JF, Xue ZJ, Shi JQ, Chen B, Chen DM, Chen NP, Li YD, Qian CD.   +8 more
europepmc   +1 more source

The Influence of Thyroid Regulators on Blood Ascorbic Acid Levels in the Chicken

, 1961
P.A. Thornton, Samir S. Deeb
openalex   +1 more source

The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli [PDF]

, 1968
J. Palmer, V. Moses
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

A metabolic switch in the TCA cycle: a regulator of intestinal stem cell fate during tissue regeneration. [PDF]

Signal Transduct Target Ther
You DG, Park JH.
europepmc   +1 more source