Results 251 to 260 of about 1,314,428 (309)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Ribonucleotide reductase: regulation, regulation, regulation

Trends in Biochemical Sciences, 1992
Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. It is composed of two dissimilar subunits, R1, the large subunit containing the allosteric regulatory sites, and R2, the small subunit containing a binuclear iron center and a tyrosyl free radical.
S J, Elledge, Z, Zhou, J B, Allen
openaire   +2 more sources

Regulating the regulators

Science, 2017
Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
openaire   +2 more sources

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