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Ribonucleotide reductase: regulation, regulation, regulation
Trends in Biochemical Sciences, 1992Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. It is composed of two dissimilar subunits, R1, the large subunit containing the allosteric regulatory sites, and R2, the small subunit containing a binuclear iron center and a tyrosyl free radical.
Zheng Zhou +2 more
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How are the regulators regulated? [PDF]
The FASEB Journal, 1991 The cell-type-specific expression of many genes is determined at the level of transcription. Transcription factors, acting at promoter and enhancer elements, are involved in the control of this process. To understand the basis of this regulation it has become important to analyze the control of transcription factors themselves.
Falvey, Eileen Elisabeth +1 more
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Science, 2017
Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Science's STKE, 2007
Growth factors and nutrients, particularly amino acids, regulate cell growth and proliferation in part through the serine-threonine protein kinase mTOR (mammalian target of rapamycin). Activity of mTOR is regulated through the small guanosine triphosphatase Rheb (Ras homolog enriched in brain). Bai et al .
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Growth factors and nutrients, particularly amino acids, regulate cell growth and proliferation in part through the serine-threonine protein kinase mTOR (mammalian target of rapamycin). Activity of mTOR is regulated through the small guanosine triphosphatase Rheb (Ras homolog enriched in brain). Bai et al .
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Journal of Economic Issues, 1985
The controversy over the level and nature of regulatory activities in the economy is shaped by both the methodology of analysis and its perspective. Most of the tools used to evaluate specific portions of the regulatory system are embedded in neoclassical economic theory.
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The controversy over the level and nature of regulatory activities in the economy is shaped by both the methodology of analysis and its perspective. Most of the tools used to evaluate specific portions of the regulatory system are embedded in neoclassical economic theory.
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Nature, 2000
The list of proteins whose activity is controlled by transport into different subcellular compartments keeps growing. The latest additions are two regulators of gene expression.
Gerald R. Crabtree, Scott Stewart
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The list of proteins whose activity is controlled by transport into different subcellular compartments keeps growing. The latest additions are two regulators of gene expression.
Gerald R. Crabtree, Scott Stewart
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Science, 1999
Major histocompatibility complex (MHC) class II antigens are almost exclusively expressed on immune cells such as dendritic cells and activated macrophages. It is known that their expression is necessary for the activation of lymphocytes and for a healthy immune response.
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Major histocompatibility complex (MHC) class II antigens are almost exclusively expressed on immune cells such as dendritic cells and activated macrophages. It is known that their expression is necessary for the activation of lymphocytes and for a healthy immune response.
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The University of Chicago Law Review, 1996
Since the 1970s, there has been a tremendous growth in government regulation pertaining to risk and the environment. These efforts have emerged quite legitimately because market processes alone cannot fully address risk-related concerns.' Without some kind of regulation or liability, for example, firms lack appropriate incentives to restrict their ...
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Since the 1970s, there has been a tremendous growth in government regulation pertaining to risk and the environment. These efforts have emerged quite legitimately because market processes alone cannot fully address risk-related concerns.' Without some kind of regulation or liability, for example, firms lack appropriate incentives to restrict their ...
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Thymosin α1: the regulator of regulators?
Annals of the New York Academy of Sciences, 2010The peripheral immune system can promote either immunity or tolerance when presented with new antigens. Current knowledge withholds that populations of suppressor or regulatory T cells (Treg cells) constitute a pivotal mechanism of immunological tolerance.
Pierluigi, B +9 more
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The Regulations and the Regulators
1976The police were structurally fragmented and often divided by interest and ambition but they shared a number of basic ideas about the provisioning question. This chapter deals with the police view of the grain trade and the ways in which the police translated their attitudes into action.
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