The response regulator CrsR positively regulates ansamitocin P-3 biosynthesis in <i>Actinosynnema pretiosum</i>. [PDF]
Zhang P +7 more
europepmc +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Two-component systems as potential therapeutic targets in <i>Neisseria</i> pathogenesis. [PDF]
Haldar T, Saroj SD.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Abscisic acid at the crossroad of abiotic stress responses and plant-microbe interactions. [PDF]
Makris A +3 more
europepmc +1 more source
The LuxR family regulator SAV111 enhances avermectin production by binding to aveA1 gene promoter in Streptomyces avermitilis. [PDF]
Luo S +7 more
europepmc +1 more source
Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH. [PDF]
Prophete MD +3 more
europepmc +1 more source
Transcription regulator TrtA modulates oxygen stress response in <i>Treponema denticola</i>. [PDF]
Kitamura Y +6 more
europepmc +1 more source

