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AP-1 as a regulator of cell life and death
Nature Cell Biology, 2002Michael Karin
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Alternative splicing as a regulator of development and tissue identity
Nature Reviews Molecular Cell Biology, 2017 Jimena Giudice
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Ribonucleotide reductase: regulation, regulation, regulation
Trends in Biochemical Sciences, 1992Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. It is composed of two dissimilar subunits, R1, the large subunit containing the allosteric regulatory sites, and R2, the small subunit containing a binuclear iron center and a tyrosyl free radical.
S J, Elledge, Z, Zhou, J B, Allen
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The lung microenvironment: an important regulator of tumour growth and metastasis
Nature Reviews Cancer, 2018 Nasser K Altorki +2 more
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ATR: an essential regulator of genome integrity
Nature Reviews Molecular Cell Biology, 2008 Karlene A Cimprich, David Cortez
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On the Sample Complexity of the Linear Quadratic Regulator
Foundations of Computational Mathematics, 2017This paper addresses the optimal control problem known as the linear quadratic regulator in the case when the dynamics are unknown. We propose a multistage procedure, called Coarse-ID control, that estimates a model from a few experimental trials ...
Sarah Dean +4 more
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Science, 2017
Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Regulating 'Unnecessary Surgery' Regulations
Archives of Ophthalmology, 1978To the Editor. —Dr Wong's special communication entitled, "Indications for Cataract Surgery: Psycholinguistic Considerations," which appeared in the MarchArchives(96:526-528, 1978), superbly states the problems facing both patient and surgeon in the often-difficult process of deciding the point at which to intervene surgically in a patient with ...
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2017
Self-regulation encompasses a wide range of arrangements, from private ordering without resort to legal rules to state-enforced systems of delegated rules. Transaction cost analysis has been used to explain how private ordering emerges, and the advantages, but also the difficulties, of state delegation have been illustrated using a comparative approach.
CARBONARA, EMANUELA, A. Ogus
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Self-regulation encompasses a wide range of arrangements, from private ordering without resort to legal rules to state-enforced systems of delegated rules. Transaction cost analysis has been used to explain how private ordering emerges, and the advantages, but also the difficulties, of state delegation have been illustrated using a comparative approach.
CARBONARA, EMANUELA, A. Ogus
openaire +3 more sources
TGF-beta: a master immune regulator
Expert opinion on therapeutic targets, 2020Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune
C. Larson +6 more
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