Results 91 to 100 of about 6,034,940 (339)

Paediatric formulations—part of the repurposing concept?

Frontiers in Medicine
The lack of available appropriate paediatric formulations is a significant challenge for optimal treatment in children. The resulting manipulation of adult medicines implies risk of medication errors, inaccurate dosing, and unacceptable dosage forms ...
Siri Wang, Viviana Giannuzzi
doaj   +1 more source

PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants

Nucleic Acids Res., 2016
With the goal of providing a comprehensive, high-quality resource for both plant transcription factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF database PlantTFDB to version 4.0 (http://planttfdb.cbi.pku.edu.cn ...
Jinpu Jin, Feng Tian, Dechang Yang, Yuqi Meng, Lei Kong, Jingchu Luo, Ge Gao   +6 more
semanticscholar   +1 more source

Regulatory systems, institutions and practices [PDF]

, 2014
Regulation is a fact of life. It affects the food we eat, the safety of our workplace, the goods and services we buy and sell and the quality of our natural environment.
Judy Kavanagh, Steven Bailey
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

PlantRegMap: charting functional regulatory maps in plants

Nucleic Acids Res., 2019
With the goal of charting plant transcriptional regulatory maps (i.e. transcription factors (TFs), cis-elements and interactions between them), we have upgraded the TF-centred database PlantTFDB (http://planttfdb.cbi.pku.edu.cn/) to a plant regulatory ...
Feng Tian, Dechang Yang, Yuqi Meng, Jinpu Jin, Ge Gao   +4 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Benchmarking algorithms for gene regulatory network inference from single-cell transcriptomic data

Nature Methods, 2019
We present a systematic evaluation of state-of-the-art algorithms for inferring gene regulatory networks from single-cell transcriptional data.
Aditya Pratapa, A. Jalihal, Jeffrey N. Law, Aditya Bharadwaj, T. Murali   +4 more
semanticscholar   +1 more source

Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators [PDF]

, 2011
Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions.
A. M. Sengupta, Arya, Banzhaf, Blackwood, Bondarenko, Bushey, Bustin, Capelson, Carter, Chodaparambil, Corces, Cremer, Cui, Dekker, Dorsett, Gerasimova, Geyer, Geyer, Hahnfeldt, Langowski, Luger, Moore, Nielsen, Nobrega, P. Schedl, Phair, Polikanov, Rochman, S. Mukhopadhyay, Savitskaya, Schermelleh, Simonis, Tolhuis, V. M. Studitsky, Valenzuela, van den Engh, Wallace, West, Zheng, Zhou   +39 more
core   +3 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

European regulation of insurance market – challenges of the implementation in Montenegro

Acta Economica, 2013
Market position and competitive advantage of insurers in the integrated Montenegrin insurance market, can be sustained by improving professionalism, taking into account the needs of the insured, strengthening of financial capacity with the aim that ...
Милијана Нововић, Милан Лакићевић   +1 more
doaj   +1 more source