Results 101 to 110 of about 6,202,519 (294)

PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants

Nucleic Acids Res., 2016
With the goal of providing a comprehensive, high-quality resource for both plant transcription factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF database PlantTFDB to version 4.0 (http://planttfdb.cbi.pku.edu.cn ...
Jinpu Jin, Feng Tian, Dechang Yang, Yuqi Meng, Lei Kong, Jingchu Luo, Ge Gao   +6 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Simulation Tool for Tuning and Performance Analysis of Robust, Tracking, Disturbance Rejection and Aggressiveness Controller

Algorithms, 2019
The RTD-A (robust, tracking, disturbance rejection and aggressiveness) controller is a novel control scheme that substitutes the classical proportional integral derivative (PID) controller.
Veeramani Bagyaveereswaran, Subramaniam Umashankar, Pachiyappan Arulmozhivarman   +2 more
doaj   +1 more source

Regulatory observer: international and Australian regulatory developments and decisions [PDF]

Provides information and updates about international (focusing on the OECD) and Australian regulatory developments and decisions. Summary In this issue: European Commission funding for transport infrastructure International regulatory round-up ...

core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regulatory requirements for marketing fixed dose combinations

Perspectives in Clinical Research, 2010
The development of fixed-dose combinations (FDCs) is becoming increasingly important from a public health perspective. FDCs have advantages when there is an identifiable patient population for whom treatment with a particular combination of actives in a ...
B G Jayasheel
doaj   +1 more source

Regulatory Strategies [PDF]

Over the years, there has been a shift from a wide command-and-control style of supervision whereby the regulator imposes detailed rules with which regulators supervise to one which consists of risk based regulatory strategies. ‘Enforced Self Regulation’,
Ojo, Marianne
core   +1 more source

Benchmarking algorithms for gene regulatory network inference from single-cell transcriptomic data

Nature Methods, 2019
We present a systematic evaluation of state-of-the-art algorithms for inferring gene regulatory networks from single-cell transcriptional data.
Aditya Pratapa, A. Jalihal, Jeffrey N. Law, Aditya Bharadwaj, T. Murali   +4 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Leveraging patient experience data to guide medicines development, regulation, access decisions and clinical care in the EU

Frontiers in Medicine
Patient experience data (PED), provided by patients/their carers without interpretation by clinicians, directly capture what matters more to patients on their medical condition, treatment and impact of healthcare.
Diogo Almeida, Diogo Almeida, Denise Umuhire, Rosa Gonzalez-Quevedo, Ana António, Juan Garcia Burgos, Patrice Verpillat, Nathalie Bere, Bruno Sepodes, Bruno Sepodes, Carla Torre, Carla Torre   +11 more
doaj   +1 more source