Results 151 to 160 of about 6,202,519 (294)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Access in all areas? A round-up of developments in market access and health technology assessment: part 10

Journal of Comparative Effectiveness Research
In this update, we examine the US’ Food and Drug Administration (FDA) Commissioner’s National Priority Voucher pilot program; The Netherlands’ Zorginstituut Nederland (ZIN) implementation framework for the EU HTA Regulation; and Italy’s Agenzia ...
Sreeram V Ramagopalan, Annie Jullien Pannelay   +1 more
doaj   +1 more source

ENVIRONMENTAL REGULATORY REFORM: DISCUSSION [PDF]

Environmental Economics and Policy,
Park, William M.
core   +1 more source

Plant cis-acting regulatory DNA elements (PLACE) database: 1999

Nucleic Acids Res., 1999
K. Higo, Y. Ugawa, M. Iwamoto, Tomoko Korenaga   +3 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Regulatory advice 8 : Guidance for providers about condition of registration F1 : transparency information [PDF]

, 2020

core  

Regulatory Issues in Biosecurity [PDF]

The management of biosecurity risks (risks to the production sector, to indigenous biodiversity, and to public health) involves the exercise of extensive regulatory powers both at the border and within New Zealand.
Chris Pinfield
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Editorial: Female urogenital devices used during their lifetime—managing menstruation including pelvic health

Frontiers in Reproductive Health
Catherine C. Davis, Kenneth W. Miller, Julie A. Peterson   +2 more
doaj   +1 more source

Regulatory reform : integrating paradigms [PDF]

The Subprime crisis largely resulted from failures to internalize systemic risk evenly across financial intermediaries and recognize the implications of Knightian uncertainty and mood swings.
de la Torre, Augusto, Ize, Alain
core