Results 11 to 20 of about 6,034,940 (339)

Biopesticides, Regulatory Innovation and the Regulatory State [PDF]

open access: yesPublic Policy and Administration, 2009
This article analyses regulatory innovation. It considers, in particular, how a regulatory environmental agency has been encouraged to innovate in the area of biopesticides. The literature on regulatory innovation is reviewed, the discussion situated within Moran's theory of the regulatory state.
Greaves, Justin
openaire   +3 more sources

Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease

open access: yesGut and Liver, 2019
Background/AimsThe current study aims to investigate the protective effects of Bifidobacterium infantis on the abnormal immune response to inflammatory bowel disease (IBD) in dextran sodium sulfate (DSS)-induced colitis.Methods : Eight-week-old BALB/c ...
Linyan Zhou   +4 more
doaj   +1 more source

The GTEx Consortium atlas of genetic regulatory effects across human tissues

open access: yesScience, 2019
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations.
F. Aguet   +51 more
semanticscholar   +1 more source

Vaccine Licensure in the Absence of Human Efficacy Data

open access: yesVaccines, 2022
Clinical vaccine development and regulatory approval generally occurs in a linear, sequential manner: Phase 1: safety, immunogenicity; Phase 2: immunogenicity, safety, dose ranging, and preliminary efficacy; Phase 3: definitive efficacy, safety, lot ...
Courtney L. Finch   +9 more
doaj   +1 more source

Regulatory ripples [PDF]

open access: yesNature Immunology, 2010
Regulatory T cells come in many different forms depending on their mode of action or developmental origin. Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iTR35 cells', which may have an important role in the phenomenon of infectious tolerance.
Yasmine, Belkaid, Wanjun, Chen
openaire   +2 more sources

SCENIC: Single-cell regulatory network inference and clustering

open access: yesNature Methods, 2017
We present SCENIC, a computational method for simultaneous gene regulatory network reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic.aertslab.org).
S. Aibar   +13 more
semanticscholar   +1 more source

Analysis of the Regulatory Science Applied to a Single Portfolio of Eight Biosimilar Product Approvals by Four Key Regulatory Authorities

open access: yesPharmaceuticals, 2021
Slow uptake of biosimilars in some regions is often attributed to a lack of knowledge combined with concerns about safety and efficacy. To alleviate physician and patient apprehensions, regulatory reviews from four major regulatory authorities (RAs ...
Beverly Ingram   +3 more
doaj   +1 more source

New Regulations on Medical Devices in Europe: Are They an Opportunity for Growth?

open access: yesAdministrative Sciences, 2020
Increasing demand for modern treatments and significant profit margins are strong incentives for investors and producers. However, the production and use of medical devices is subject to a number of laws, regulations, strict standards, and certification ...
Petra Maresova   +4 more
doaj   +1 more source

Regulatory quality and performance in EU network industries: Evidence on telecommunications, gas and electricity [PDF]

open access: yes, 2009
This article provides empirical evidence on ex ante and ex post indicators of regulatory quality and the relationship between those indicators and market performance in liberalised EU-15 network industries. It finds a low level of regulatory independence
Frankfurter   +9 more
core   +1 more source

Development and function of regulatory innate lymphoid cells

open access: yesFrontiers in Immunology, 2022
Innate lymphoid cells (ILCs) are a critical element of the innate immune system and are potent producers of pro-inflammatory cytokines. Recently, however, the production of the anti-inflammatory cytokine IL-10 has been observed in all ILC subtypes (ILC1s,
Christopher M. Thomas   +3 more
doaj   +1 more source

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