Results 11 to 20 of about 6,202,519 (294)
The GTEx Consortium atlas of genetic regulatory effects across human tissues
Science, 2019 The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations.
F. Aguet +51 more
semanticscholar +1 more source
Vaccine Licensure in the Absence of Human Efficacy Data
Vaccines, 2022 Clinical vaccine development and regulatory approval generally occurs in a linear, sequential manner: Phase 1: safety, immunogenicity; Phase 2: immunogenicity, safety, dose ranging, and preliminary efficacy; Phase 3: definitive efficacy, safety, lot ...
Courtney L. Finch +9 more
doaj +1 more source
SCENIC: Single-cell regulatory network inference and clustering
Nature Methods, 2017 We present SCENIC, a computational method for simultaneous gene regulatory network reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic.aertslab.org).
S. Aibar +13 more
semanticscholar +1 more source
Pharmaceuticals, 2021 Slow uptake of biosimilars in some regions is often attributed to a lack of knowledge combined with concerns about safety and efficacy. To alleviate physician and patient apprehensions, regulatory reviews from four major regulatory authorities (RAs ...
Beverly Ingram +3 more
doaj +1 more source
Biopesticides, regulatory innovation and the regulatory state [PDF]
, 2009 This article analyses regulatory innovation. It considers, in particular, how a regulatory environmental agency has been encouraged to innovate in the area of biopesticides.
Greaves, Justin
core +1 more source
Molecules and Cells, 2010 Genome-scale studies have revealed extensive, cell type-specific colocalization of transcription factors, but the mechanisms underlying this phenomenon remain poorly understood.
S. Heinz +9 more
semanticscholar +1 more source
, 2008 Over the years, there has been a shift from a wide command-and-control style of supervision whereby the regulator imposes detailed rules with which regulators supervise to one which consists of risk based regulatory strategies.
Ojo, Mariane.B.
core +3 more sources
New Regulations on Medical Devices in Europe: Are They an Opportunity for Growth?
Administrative Sciences, 2020 Increasing demand for modern treatments and significant profit margins are strong incentives for investors and producers. However, the production and use of medical devices is subject to a number of laws, regulations, strict standards, and certification ...
Petra Maresova +4 more
doaj +1 more source
Regulatory quality and performance in EU network industries: Evidence on telecommunications, gas and electricity [PDF]
, 2009 This article provides empirical evidence on ex ante and ex post indicators of regulatory quality and the relationship between those indicators and market performance in liberalised EU-15 network industries. It finds a low level of regulatory independence
Frankfurter +9 more
core +1 more source
Development and function of regulatory innate lymphoid cells
Frontiers in Immunology, 2022 Innate lymphoid cells (ILCs) are a critical element of the innate immune system and are potent producers of pro-inflammatory cytokines. Recently, however, the production of the anti-inflammatory cytokine IL-10 has been observed in all ILC subtypes (ILC1s,
Christopher M. Thomas +3 more
doaj +1 more source