Results 11 to 20 of about 2,165,804 (269)
Gut and Liver, 2019 Background/AimsThe current study aims to investigate the protective effects of Bifidobacterium infantis on the abnormal immune response to inflammatory bowel disease (IBD) in dextran sodium sulfate (DSS)-induced colitis.Methods : Eight-week-old BALB/c ...
Linyan Zhou +4 more
doaj +1 more source
Nature Immunology, 2010 Regulatory T cells come in many different forms depending on their mode of action or developmental origin. Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iTR35 cells', which may have an important role in the phenomenon of infectious tolerance.
Yasmine, Belkaid, Wanjun, Chen
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Vaccine Licensure in the Absence of Human Efficacy Data
Vaccines, 2022 Clinical vaccine development and regulatory approval generally occurs in a linear, sequential manner: Phase 1: safety, immunogenicity; Phase 2: immunogenicity, safety, dose ranging, and preliminary efficacy; Phase 3: definitive efficacy, safety, lot ...
Courtney L. Finch +9 more
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Pharmaceuticals, 2021 Slow uptake of biosimilars in some regions is often attributed to a lack of knowledge combined with concerns about safety and efficacy. To alleviate physician and patient apprehensions, regulatory reviews from four major regulatory authorities (RAs ...
Beverly Ingram +3 more
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Biopesticides, Regulatory Innovation and the Regulatory State [PDF]
Public Policy and Administration, 2009 This article analyses regulatory innovation. It considers, in particular, how a regulatory environmental agency has been encouraged to innovate in the area of biopesticides. The literature on regulatory innovation is reviewed, the discussion situated within Moran's theory of the regulatory state.
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New Regulations on Medical Devices in Europe: Are They an Opportunity for Growth?
Administrative Sciences, 2020 Increasing demand for modern treatments and significant profit margins are strong incentives for investors and producers. However, the production and use of medical devices is subject to a number of laws, regulations, strict standards, and certification ...
Petra Maresova +4 more
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Development and function of regulatory innate lymphoid cells
Frontiers in Immunology, 2022 Innate lymphoid cells (ILCs) are a critical element of the innate immune system and are potent producers of pro-inflammatory cytokines. Recently, however, the production of the anti-inflammatory cytokine IL-10 has been observed in all ILC subtypes (ILC1s,
Christopher M. Thomas +3 more
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CTRI - Clicking to greater transparency and accountability
Perspectives in Clinical Research, 2012 A clinical trial registry (CTR) is an official platform for registering a clinical trial (CT) with an objective of providing increased transparency and access to CTs to the public at large.
Bobby George
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International Council for Harmonisation E6(R2) addendum: Challenges of implementation
Perspectives in Clinical Research, 2017 The International Council for Harmonisation (ICH) E6 – good clinical practice (GCP) (R2) addendum – was released in 2016 to encourage implementation of improved approaches for the management of clinical trials.
Arun Bhatt
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Repair of thermoplastic composites: an overview
Advanced Manufacturing: Polymer & Composites Science, 2022 An extensive review of literature is conducted to present the evolution of the field of repair of thermoplastic composites (TPC’s) from when it was first mentioned in 1980.
J. Barroeta Robles +3 more
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