Results 191 to 200 of about 2,165,804 (269)

Downregulation is the dominant effect of new regulatory mutations in a fungal pathogen. [PDF]

Microb Genom
Sampaio AM, Croll D.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Why advanced therapy medicinal products struggle in clinical translation: an in-depth analysis of developmental challenges in the EU. [PDF]

Front Med (Lausanne)
Van Isterdael C, Mugarza E, Fischer P, Debackere K, Vandenberghe P, Martin Lluesma S, Van Eldere J, Huys I.   +7 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Transcriptomic Signatures Associated with Doxorubicin Treatment in Liposarcoma Reveal Coordinated Regulatory Patterns. [PDF]

Diseases
Khaleel A, Khaleel S, Ahmed RM, Al Athamneh A, Elsahoryi NA, Ali Agha ASA.   +5 more
europepmc   +1 more source

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 15

Journal of Comparative Effectiveness Research
Alejandra Castanon, Benjamin D Bray, Sreeram V Ramagopalan   +2 more
doaj   +1 more source

Circular RNAs in Cardiovascular Diseases: From Regulatory Networks to Functional Effectors. [PDF]

Int J Mol Sci
Rebolledo C, Salazar LA.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Enactment and Implementation of Korea's Digital Medical Products Act: A Comparative Study Exploring Policy Implications. [PDF]

J Korean Med Sci
Chung J, Shin Y, Kim G, Lee M, Shin J.
europepmc   +1 more source