Results 261 to 270 of about 6,202,519 (294)

Non-Coding Regulatory Variants in Autoimmune Disease: Biological Mechanisms, Immune Context, and Integrative Multi-Omics Interpretation. [PDF]

Biology (Basel)
Ali Agha ASA, Al-Zaki NA, Alshammari SAN, Odeh L, Obekh R, Sameer N, M Askari H, Hakooz N, Al-Adham I, Collier PJ.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors. [PDF]

Biology (Basel)
Ma J, Zhang X, Jiang S, Fei S, Kong L, Pan M, Ma W, Ren W.   +7 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Addressing Unmet Medical Needs in Drug Development: Assessment and Implications for Regulatory and Clinical Development Strategies. [PDF]

J Mark Access Health Policy
Domingo-Esteban C, Heikkinen I, Hefting N.   +2 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Bridging evidence worlds: policy and practice pathways for integrating clinical trials and real-world data in drug development and HTA. [PDF]

Front Pharmacol
Sagkriotis A.
europepmc   +1 more source

Artificial Intelligence as a Disruptive Force in Pharmaceutical Innovation: Transforming Discovery, Development, and Manufacturing. [PDF]

Drug Des Devel Ther
Herdiana Y, Mohammed AFA, Kautsar AP, Sopyan I, Wathoni N.   +4 more
europepmc   +1 more source

The doctor is not in, but the Chatbot is: Utah's experience regulating mental health AI. [PDF]

NPJ Digit Med
de Lacy N, Boyd Z.
europepmc   +1 more source