Results 271 to 280 of about 6,034,940 (339)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effect of illness perception on self-regulatory fatigue in older adult patients with hypertension: chain-mediating role of self-efficacy and coping style. [PDF]

Front Public Health
Lu T, Shi L, Zhang H, Zhang J, Shen Y.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Ensembl’s regulatory annotation for human, mouse, livestock, and aquaculture species

Ilsley GR, Lins PRB, Merino GA, Urbina-Gómez D, Harrison PW.   +4 more
europepmc   +1 more source

Sex-Specific doublesex Regulation Targeting the Color-Patterning Gene h Underlies the Evolution of Wing Sexual Dimorphism in the Harlequin Ladybug Harmonia axyridis. [PDF]

Evol Dev
Yeki S, Kato K, Morita S, Shimomura K, Niimi T, Hinomoto N, Daimon T, Ando T.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Regulatory B Cells in Tumor Microenvironment. [PDF]

Curr Issues Mol Biol
Cai Z, Xie L.
europepmc   +1 more source

Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria. [PDF]

Mol Biol Evol
Bai Y, Min Y, Liu S, Hu Y, Jin S, Yu H, Kong L, Macqueen DJ, Du S, Li Q.   +9 more
europepmc   +1 more source

Regulatory QTLs affecting miRNA-mRNA interactions in cancer: mechanisms, methods, and clinical implications. [PDF]

Front Mol Biosci
Kumar V, Shukla R, Chaudhary A, Gautam M.   +3 more
europepmc   +1 more source