Results 51 to 60 of about 6,202,519 (294)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Evaluation of CD4+ CD25+/high CD127low/- Regulatory T-Cells in Different Stages of Psoriatic Arthritis Patients

Advanced Biomedical Research
Background: Psoriatic arthritis (PsA) is a systemic auto-immune condition characterized by diverse and distinctive inflammation, affecting both musculoskeletal and extra-articular systems.
Roya Safari, Abdolhussein Shakurnia, Ata Ghadiri, Elham Rajaei, Karim Mowla, Maryam Haidari   +5 more
doaj   +1 more source

Extemporaneous Compounding Practice for Dermatologic Preparations in Ethiopian Public Hospitals: Regulatory Requirements and Quality Concerns

Risk Management and Healthcare Policy, 2021
Muluken Nigatu Selam,1 Andualem Ababu2 1Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2Pharmaceutical and Medical Equipment Directorate (PMED), Ministry of ...
Selam MN, Ababu A
doaj  

Lawyer Speech in the Regulatory State [PDF]

, 2016
A lawyer’s speech as advisor and advocate not only holds First Amendment value for the client and for the public, but also for the functioning of American democracy.
Knake, Renee Newman
core   +2 more sources

Regulatory mechanisms of PD-1/PD-L1 in cancers

Molecular Cancer
Immune evasion contributes to cancer growth and progression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions.
Xin Lin, Kuan Kang, Pan Chen, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, Mei Yi, Bo Xiang   +7 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Aptamer based immunotherapy: a potential solid tumor therapeutic

Frontiers in Immunology
Aptamer-based immunotherapy can be a new hope for treating solid tumors with personalized and specific approaches toward cancer therapies. Aptamers are small synthetic single-stranded nucleic acids that may bring in a paradigm shift in treating solid ...
Sarmilah Mathavan, Sarmilah Mathavan, Yew Joon Tam, Khairul Mohd Fadzli Mustaffa, Gee Jun Tye, Gee Jun Tye   +5 more
doaj   +1 more source

Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Pharmaceuticals, 2023
Various formulations of polymeric micelles, tiny spherical structures made of polymeric materials, are currently being investigated in preclinical and clinical settings for their potential as nanomedicines.
Qi Wang, Keerthi Atluri, Amit K. Tiwari, R. Jayachandra Babu   +3 more
doaj   +1 more source

The hardwiring of development: Organization and function of genomic regulatory systems [PDF]

, 1997
The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the ...
Arnone, Maria I., Davidson, Eric H.
core  

Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo [PDF]

, 2008
We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm.
Alifragis, Davidson, Dawson, E. H. Davidson, Fisher, Giagtzoglou, Gyory, Howard-Ashby, Howard-Ashby, J. Smith, Kuo, Lee, Livi, Materna, McClay, Minokawa, Oellers, Oliveri, Osipovich, Peterson, Ransick, Revilla-i-Domingo, Rizzo, Robertson, Sea Urchin Genome Sequencing Consortium, Sherwood, Smith, Smith, Thirunavukkarasu, Tietze, Tu, Walton, Wikramanayake, Yu, Yuh   +34 more
core   +3 more sources