Results 61 to 70 of about 6,034,940 (339)
Aptamer based immunotherapy: a potential solid tumor therapeutic
Frontiers in ImmunologyAptamer-based immunotherapy can be a new hope for treating solid tumors with personalized and specific approaches toward cancer therapies. Aptamers are small synthetic single-stranded nucleic acids that may bring in a paradigm shift in treating solid ...
Sarmilah Mathavan +5 more
doaj +1 more source
Building biorepositories in the midst of a pandemic
Journal of Clinical and Translational Science, 2021 Biospecimen repositories play a vital role in enabling investigation of biologic mechanisms, identification of disease-related biomarkers, advances in diagnostic assays, recognition of microbial evolution, and characterization of new therapeutic targets ...
Jennifer A. Croker +7 more
doaj +1 more source
Metabolic support of tumor-infiltrating regulatory T cells by lactic acid
Nature, 2020 Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells1,2.
M. Watson +16 more
semanticscholar +1 more source
Regulatory activity revealed by dynamic correlations in gene expression noise [PDF]
, 2008 Gene regulatory interactions are context dependent, active in some cellular states but not in others. Stochastic fluctuations, or 'noise', in gene expression propagate through active, but not inactive, regulatory links^(1,2).
Cox, Robert Sidney, III +4 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The hardwiring of development: Organization and function of genomic regulatory systems [PDF]
, 1997 The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the ...
Arnone, Maria I., Davidson, Eric H.
core
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Fake Qualifications and the Challenge of regulating Higher Education in Southern Africa
Modern Africa, 2018 This article examines the prevalence and implications of fake qualifications and the need for an effective regulatory regime to contain fake higher education qualifications.
Ignasio M. Jimu
doaj +1 more source